Fusidate Sodium | Fusidic Acid Sodium | Bacteriostatic Antibiotic

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夫西地酸钠 /Fusidate Sodium {[allProObj[0].p_purity_real_show]}

货号：A110028 同义名： Fusidic Acid Sodium;Sodium fusidate

Fusidic Acid Sodium is an antibiotic working by inhibition of protein synthesis in prokaryotes through inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Fusidate Sodium 化学结构
CAS号：751-94-0

Fusidate Sodium 3D分子结构
CAS号：751-94-0

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Fusidate Sodium 纯度/质量文件产品仅供科研

货号：A110028 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Fusidate Sodium 生物活性

描述

Fusidic acid as well as its sodium salt (Fusidic Acid Sodium), fusidin, is a relatively atoxic antibiotic used mainly in the treatment of staphylococcal infections. The drug has shown promise in preventing the disease in animal models of IDDM (Insulin-dependent diabetes mellitus) and in a preliminary trial in IDDM patients^[3]. Fusidic acid (Fusidic Acid Sodium), a steroidal antibiotic, possesses antimicrobial, antioxidant, and anti-inflammatory properties. Fusidic acid can protect C6 glial cells against cytotoxicity, through the regulation of AMPK (adenosine monophosphate-activated protein kinase) pathway and apoptotic events^[4]. Fusidic acid sodium salt (fusidic acid or FA) as an inhibitor of PRPK (p53-related protein kinase), and show that FA combined with 5-fluorouracil (5-FU) inhibited PRPK activity and colon cancer metastasis to the lung in mice^[5]. Fusidic acid was potent (MICs, 0.125 to 0.5 μg/ml; a single 500-mg dose of fusidic acid at 8 h averaged 8 to 12. 5 μg/ml with 91 to 97% protein binding) against all MRSA(methicillin-resistant Staphylococcus aureus) strains^[6].

Fusidate Sodium 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03395132	Infected Atopic Dermatitis/Ecz... 展开 >>ema 收起 <<	Phase 3	Recruiting	January 14, 2020	China ... 展开 >> Children's Hospital, Capital Institute of Pediatrics Not yet recruiting Beijing, China, 100020 Beijing Children's Hospital, Capital Medical University Not yet recruiting Beijing, China, 100045 Peking Union Medical College Hospital Not yet recruiting Beijing, China, 100730 The First Affiliated Hospital of Chongqing Medical University Not yet recruiting Chongqing, China The First Hospital of Dalian Medical University Not yet recruiting Dalian, China, 116011 The Second Hospital of Dalian Medical University Not yet recruiting Dalian, China, 116023 Guangdong General Hospital Recruiting Guangzhou, China, 510080 Dermatology Hospital, China Academy of Medicine and Science Recruiting Nanjing, China, 210042 The Affiliated Hospital of Qingdao University Not yet recruiting Qingdao, China Shanghai Huashan Hospital Recruiting Shanghai, China, 200040 Children's Hospital of Shanghai Not yet recruiting Shanghai, China, 200062 General Hospital of Shenyang Military Not yet recruiting Shenyang, China, 110000 The People's Hospital of Liaoning Province Recruiting Shenyang, China, 110016 The First Affiliated Hospital of Soochow University Not yet recruiting Suzhou, China, 215006 Tongji Hospital of Tongji Medical College of Huazhong Univ. of Science & Technology Recruiting Wuhan, China, 430030 Tangdu Hospital Not yet recruiting Xi'an, China, 710038 收起 <<
NCT00133874	Skin Infections, Bacterial	Phase 3	Completed	-	-
NCT03052348	Severe Atopic Dermatitis	Not Applicable	Not yet recruiting	August 30, 2018	South Africa ... 展开 >> Nelson Mandela Academic Hospital Not yet recruiting Mthatha, Eastern Cape, South Africa, 5099 Contact: Avumile Mankahla, MBCHB 0836547566 Mankahla@gmail.com Contact: Noluvuyo Qikani, MBCHB 0833821188 lmvuyo@gmail.com King Edward Hospital Not yet recruiting Durban, KwaZulu Natal, South Africa, 4013 Contact: Ncoza Dlova, MBCHB 0312604530 Dlovan@ukzn.ac.za Red Cross War Memorial Children's Hospital Cape Town, Western Cape, South Africa, 7700 收起 <<

Fusidate Sodium 参考文献

[1]Milenkovc M, Arsenovic-Ranin N, et al. Fusidin ameliorates experimental autoimmune myocarditis in rats by inhibiting TNF-alpha production. Pharmazie. 2007 Jun;62(6):445-8.

[2]Nicoletti F, Di Marco R, et al. Sodium fusidate ameliorates the course of diabetes induced in mice by multiple low doses of streptozotocin. J Autoimmun. 2000 Dec;15(4):395-405.

[3]Nicoletti F, Meroni PL, Bendtzen K. Fusidic acid and insulin-dependent diabetes mellitus. Autoimmunity. 1996;24(3):187–197

[4]Park E, Kim DK, Kim CS, Kim JS, Kim S, Chun HS. Protective effects of fusidic acid against sodium nitroprusside-induced apoptosis in C6 glial cells. Neuroreport. 2019;30(17):1222–1229

[5]Zykova T, Zhu F, Wang L, et al. Targeting PRPK Function Blocks Colon Cancer Metastasis. Mol Cancer Ther. 2018;17(5):1101–1113

[6]McGhee P, Clark C, Credito K, et al. In vitro activity of fusidic acid (CEM-102, sodium fusidate) against Staphylococcus aureus isolates from cystic fibrosis patients and its effect on the activities of tobramycin and amikacin against Pseudomonas aeruginosa and Burkholderia cepacia. Antimicrob Agents Chemother. 2011;55(5):2417–2419

Fusidate Sodium 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.28mL

1.86mL

0.93mL

18.56mL

3.71mL

1.86mL

Fusidate Sodium 技术信息

CAS号	751-94-0
分子式	C₃₁H₄₇NaO₆
分子量	538.691

别名	Fusidic Acid Sodium;Sodium fusidate;Fusidic Acid (sodium salt);Fucidin;SQ-16360;Fusidic acid sodium salt
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(194.92 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 100 mg/mL(185.64 mM)

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03395132	Infected Atopic Dermatitis/Ecz... 展开 >>ema 收起 <<	Phase 3	Recruiting	January 14, 2020	China ... 展开 >> Children's Hospital, Capital Institute of Pediatrics Not yet recruiting Beijing, China, 100020 Beijing Children's Hospital, Capital Medical University Not yet recruiting Beijing, China, 100045 Peking Union Medical College Hospital Not yet recruiting Beijing, China, 100730 The First Affiliated Hospital of Chongqing Medical University Not yet recruiting Chongqing, China The First Hospital of Dalian Medical University Not yet recruiting Dalian, China, 116011 The Second Hospital of Dalian Medical University Not yet recruiting Dalian, China, 116023 Guangdong General Hospital Recruiting Guangzhou, China, 510080 Dermatology Hospital, China Academy of Medicine and Science Recruiting Nanjing, China, 210042 The Affiliated Hospital of Qingdao University Not yet recruiting Qingdao, China Shanghai Huashan Hospital Recruiting Shanghai, China, 200040 Children's Hospital of Shanghai Not yet recruiting Shanghai, China, 200062 General Hospital of Shenyang Military Not yet recruiting Shenyang, China, 110000 The People's Hospital of Liaoning Province Recruiting Shenyang, China, 110016 The First Affiliated Hospital of Soochow University Not yet recruiting Suzhou, China, 215006 Tongji Hospital of Tongji Medical College of Huazhong Univ. of Science & Technology Recruiting Wuhan, China, 430030 Tangdu Hospital Not yet recruiting Xi'an, China, 710038 收起 <<
NCT00133874	Skin Infections, Bacterial	Phase 3	Completed	-	-
NCT03052348	Severe Atopic Dermatitis	Not Applicable	Not yet recruiting	August 30, 2018	South Africa ... 展开 >> Nelson Mandela Academic Hospital Not yet recruiting Mthatha, Eastern Cape, South Africa, 5099 Contact: Avumile Mankahla, MBCHB 0836547566 Mankahla@gmail.com Contact: Noluvuyo Qikani, MBCHB 0833821188 lmvuyo@gmail.com King Edward Hospital Not yet recruiting Durban, KwaZulu Natal, South Africa, 4013 Contact: Ncoza Dlova, MBCHB 0312604530 Dlovan@ukzn.ac.za Red Cross War Memorial Children's Hospital Cape Town, Western Cape, South Africa, 7700 收起 <<
NCT02569541	Refractory Bone or Joint Infec... 展开 >>tions 收起 <<	Phase 2 Phase 3	Active, not recruiting	December 2018	United States, California ... 展开 >> Fountain Valley, California, United States, 92708 San Dimas, California, United States, 91773 Sylmar, California, United States, 91432 Torrance, California, United States, 90502 United States, Florida Tamarac, Florida, United States, 33321 United States, Illinois Springfield, Illinois, United States, 62703 United States, Kentucky Louisville, Kentucky, United States, 40202 United States, Maryland Baltimore, Maryland, United States, 21218 United States, Massachusetts Boston, Massachusetts, United States, 02111 United States, Michigan Detroit, Michigan, United States, 48202 United States, Montana Butte, Montana, United States, 59701 United States, New Jersey Somers Point, New Jersey, United States, 08244 United States, North Carolina Charlotte, North Carolina, United States, 28207 United States, Ohio Cincinnati, Ohio, United States, 45219 Cleveland, Ohio, United States, 44195 United States, Pennsylvania Haverford, Pennsylvania, United States, 19041 Malvern, Pennsylvania, United States, 19355 Philadelphia, Pennsylvania, United States, 19107 United States, Texas Houston, Texas, United States, 77030 收起 <<
NCT02570490	Acute Bacterial Skin and Skin ... 展开 >>Structure Infections 收起 <<	Phase 3	Completed	-	-

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Fusidate Sodium 生物活性

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Fusidate Sodium 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Fusidate Sodium 质控信息

Fusidate Sodium 生物活性

Fusidate Sodium 临床研究

Fusidate Sodium 参考文献

Fusidate Sodium 实验方案

Fusidate Sodium 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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