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呋喃唑酮 /Furazolidone {[allProObj[0].p_purity_real_show]}

货号：A515238 同义名： Furoxone;Trifurox

Furazolidone is a Nitrofuran-derived anti-bacterial agent and monoamine oxidase inhibitor.

Furazolidone 化学结构 CAS号：67-45-8
Furazolidone 化学结构
CAS号：67-45-8
Furazolidone 3D分子结构
CAS号：67-45-8
Furazolidone 化学结构 CAS号：67-45-8
Furazolidone 3D分子结构 CAS号：67-45-8
规格 价格 会员价 库存 数量
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Furazolidone 纯度/质量文件 产品仅供科研

货号：A515238 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Furazolidone 生物活性

描述 Furazolidone (FZD) is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO (Acute myeloid leukemia ) transformed cells with IC50 value of 12.7 μM[3]. Biological in vitro evaluations demonstrated that free FZD and the FZD:β-CD complexes presented significant leishmanicidal activity against L. amazonensis with IC50 values of 6.16 μg/mL and 1.83 μg/mL for the complexes prepared by kneading and lyophilization, respectively[4]. Moreover, furazolidone was more effective and better tolerated than quinacrine for the treatment of giardiasis[5]. Furazolidone is known to induce a condition of cardiomyopathy in turkeys, which could be used as a model to study alpha 1-antitrypsin deficiency in man[6].

Furazolidone 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03320538 Peptic Ulcer Disease Not Applicable Recruiting July 1, 2019 China, Jiangxi ... 展开 >> Jiangxi University of Traditional Chinese Medicine Recruiting Nanchang, Jiangxi, China, 330004 Contact: Xu Zhou, Ph.D.    +8618780085060    zhouxu_ebm@hotmail.com    Contact: Xiaofan Chen, Ph.D.    +86079187118012    841347982@qq.com 收起 <<
NCT02689583 Gastritis Gas... 展开 >>tric Ulcer 收起 << Not Applicable Unknown - -
NCT02934048 Therapeutic Duration ... 展开 >> Helicobacter Pylori Antimicrobial Susceptibility Test Eradication 收起 << Phase 4 Unknown June 2017 -

Furazolidone 参考文献

[1]Jiang X, Sun L, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335. doi: 10.1371/journal.pone.0072335. eCollection 2013.

[2]Alam MI, Paget T, et al. Formulation and advantages of furazolidone in liposomal drug delivery systems. Eur J Pharm Sci. 2016 Mar 10;84:139-45.

[3]Jiang X, Sun L, Qiu JJ, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013;8(8):e72335. Published 2013 Aug 9.

[4]Carvalho SG, Siqueira LA, Zanini MS, et al. Physicochemical and in vitro biological evaluations of furazolidone-based β-cyclodextrin complexes in Leishmania amazonensis. Res Vet Sci. 2018;119:143–153.

[5]Craft JC, Murphy T, Nelson JD. Furazolidone and quinacrine. Comparative study of therapy for giardiasis in children. Am J Dis Child. 1981;135(2):164–166.

[6]Ali BH. Some pharmacological and toxicological properties of furazolidone. Vet Res Commun. 1983;6(1):1–11.

Furazolidone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.44mL

0.89mL

0.44mL

22.21mL

4.44mL

2.22mL

44.41mL

8.88mL

4.44mL

Furazolidone 技术信息

CAS号67-45-8
分子式C8H7N3O5
分子量 225.158
别名 Furoxone;Trifurox;Furazolidon;Furazolidine;Tikofuran;Nitrofuroxon;Nitrofurazolidone;Nifulidone;NSC 6469
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 4 mg/mL(17.77 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Furazolidone | Furoxone;Trifurox;Furazolidon;Furazolidine;Tikofuran;Nitrofuroxon;Nitrofurazolidone;Nifulidone;NSC 6469 | Drug Standard | Monoamine Oxidase Inhibitor | Other Antibiotics | Antibacterial | AmBeed-信号通路专用抑制剂 | Furazolidone 纯度/质量文件 | Furazolidone 生物活性 | Furazolidone 临床数据 | Furazolidone 参考文献 | Furazolidone 实验方案 | Furazolidone 技术信息

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