产品说明书
Furazolidone
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同义名 : | Furoxone;Trifurox;Furazolidon;Furazolidine;Tikofuran;Nitrofuroxon;Nitrofurazolidone;Nifulidone;NSC 6469 |
| CAS号 : | 67-45-8 | |
| 货号 : | A515238 | |
| 分子式 : | C8H7N3O5 | |
| 纯度 : | 99% | |
| 分子量 : | 225.158 | |
| MDL号 : | MFCD00010550 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 4 mg/mL(17.77 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Furazolidone (FZD) is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO (Acute myeloid leukemia ) transformed cells with IC50 value of 12.7 μM[3]. Biological in vitro evaluations demonstrated that free FZD and the FZD:β-CD complexes presented significant leishmanicidal activity against L. amazonensis with IC50 values of 6.16 μg/mL and 1.83 μg/mL for the complexes prepared by kneading and lyophilization, respectively[4]. Moreover, furazolidone was more effective and better tolerated than quinacrine for the treatment of giardiasis[5]. Furazolidone is known to induce a condition of cardiomyopathy in turkeys, which could be used as a model to study alpha 1-antitrypsin deficiency in man[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03320538 | Peptic Ulcer Disease | Not Applicable | Recruiting | July 1, 2019 | China, Jiangxi ... 展开 >> Jiangxi University of Traditional Chinese Medicine Recruiting Nanchang, Jiangxi, China, 330004 Contact: Xu Zhou, Ph.D. +8618780085060 zhouxu_ebm@hotmail.com Contact: Xiaofan Chen, Ph.D. +86079187118012 841347982@qq.com 收起 << |
| NCT02689583 | Gastritis Gas... 展开 >>tric Ulcer 收起 << | Not Applicable | Unknown | - | - |
| NCT02934048 | Therapeutic Duration ... 展开 >> Helicobacter Pylori Antimicrobial Susceptibility Test Eradication 收起 << | Phase 4 | Unknown | June 2017 | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.44mL 0.89mL 0.44mL |
22.21mL 4.44mL 2.22mL |
44.41mL 8.88mL 4.44mL |
| 参考文献 |
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