Known to induce vomiting, substance P binds to NK-1 receptors in the abdominal vagus, the NTS and the area postrema. Compounds that block NK-1 receptors lessen emesis after cisplatin, ipecac, apomorphine and radiation therapy[3]. Aprepitant is a selective NK-1 receptor antagonist approved as a therapy for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV). Fosaprepitant is a water-soluble phosphoryl prodrug for aprepitant, which, when administered intravenously, is converted to aprepitant within 30 min via the action of ubiquitous phosphatases[3]. Injection of the NK-1 receptor antagonists fosaprepitant directly into the vicinity of the NTS neurons inhibited cisplatin-induced emesis in the ferret, which suggested fosaprepitant may exert its main anti-emetic action centrally by depressing the neural activity of the NTS neurons, with possibly some peripheral anti-emetic effect through blockade of NK-1 receptors located on vagal terminals in the gut[3]. Preclinical toxicology studies of bolus fosaprepitant administered in seconds to dogs and rats showed that concentrations of 1 mg/ml were well tolerated. Concentrations up to 25 mg/ml at low doses (2 – 4 mg/kg/day) were well tolerated in dog[4].
United States, Arizona
... 展开 >>
Mayo Clinic Arizona
Scottsdale, Arizona, United States, 85259-5499
United States, North Carolina
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States, 27157
United States, Vermont
Fletcher Allen Health Care
Burlington, Vermont, United States, 05401 收起 <<
United States, California
... 展开 >>
California Pacific Medical Center
San Francisco, California, United States, 94115
Stanford University
Stanford, California, United States, 94305-5187
United States, Kentucky
University of Louisville
Louisville, Kentucky, United States, 40202
United States, Maryland
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
United States, Michigan
University of Michigan Medical Center
Ann Arbor, Michigan, United States, 48109
United States, North Carolina
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
United States, Pennsylvania
Temple University Hospital
Philadelphia, Pennsylvania, United States, 19140
United States, Texas
Texas Tech University Health Sciences Center
El Paso, Texas, United States, 79905 收起 <<
United States, Arizona
... 展开 >>
University of Arizona Medical Center
Recruiting
Tucson, Arizona, United States, 85724
Principal Investigator: Kai Schoenhage, MD 收起 <<
China, Guangdong
... 展开 >>
Sun Yat-sen University Cancer Center
Not yet recruiting
Guangzhou, Guangdong, China, 510060
Contact: Liang Wang, Doctor +86-20-87342462 wangliang@sysucc.org.cn 收起 <<
United States, Arizona
... 展开 >>
Arizona Oncology Associates, PC-HAL
Pheonix, Arizona, United States, 85016
United States, California
The Oncology Institute of Hope and Innovation
Downey, California, United States, 90241
Compassionate Cancer Medical Center
Riverside, California, United States, 92501
United States, Indiana
Northern Indiana Research
Mishawaka, Indiana, United States, 46545
Northern Indiana Research
South Bend, Indiana, United States, 46804
United States, New York
North Shore Oncology
East Setauket, New York, United States, 11733
United States, Ohio
Gabrail Cancer Center Research
Canton, Ohio, United States, 44718 收起 <<
Germany
... 展开 >> University Hospital of Heidelberg, Department V
Recruiting
Heidelberg, Germany, 69120
Principal Investigator: Gerlinde Egerer, MD 收起 <<
United States, Kentucky
... 展开 >>
Call for Information (Investigational Site 0003)
Louisville, Kentucky, United States, 40202
United States, Tennessee
Call for Information (Investigational Site 0022)
Nashville, Tennessee, United States, 37232
Brazil
MSD
Sao Paulo, SP, Brazil, 04717-004
Mexico
MSD
Mexico City, Mexico, 1090
Spain
Merck Sharp and Dohme de Espana S.A.
Madrid, Spain, 28027
Turkey
Merck Sharp & Dohme Ilaclari Ltd. Sti
Istanbul, Turkey 收起 <<
United States, Pennsylvania
... 展开 >>
Hospital of the University of Pennsylvania Clinical Research Site
Philadelphia, Pennsylvania, United States, 19104 收起 <<
Nausea and Vomiting
... 展开 >> Stage III Squamous Cell Carcinoma of the Hypopharynx
Stage III Squamous Cell Carcinoma of the Larynx
Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity
Stage III Squamous Cell Carcinoma of the Nasopharynx
Stage III Squamous Cell Carcinoma of the Oropharynx
Stage IV Squamous Cell Carcinoma of the Hypopharynx
Stage IV Squamous Cell Carcinoma of the Larynx
Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity
Stage IV Squamous Cell Carcinoma of the Nasopharynx
Stage IV Squamous Cell Carcinoma of the Oropharynx 收起 <<
Phase 2
Terminated(Study stopped due t... 展开 >>o lack of efficacy in first 6 patients) 收起 <<
-
United States, Washington
... 展开 >>
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Seattle, Washington, United States, 98109 收起 <<
Terminated(Study terminated ea... 展开 >>rly prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.) 收起 <<
United States, Oklahoma
... 展开 >>
Jimmy Everest Center for Cancer and Blood Disorders in Children
Recruiting
Oklahoma City, Oklahoma, United States, 73104
Principal Investigator: Rene McNall-Knapp, MD 收起 <<
Japan
... 展开 >> Chubu Region Facility
Chubu, Japan
Chugoku Region Facility
Chugoku, Japan
Hokkaido Region Facility
Hokkaido, Japan
Hokuriku Region Facility
Hokuriku, Japan
Kanto Region Facility
Kanto, Japan
Kinki Region Facility
Kinki, Japan
Kyushu Region Facility
Kyushu, Japan
Shikoku Region Facility
Shikoku, Japan
Tohoku Region Facility
Tohoku, Japan 收起 <<
United States, Indiana
... 展开 >>
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
United States, Missouri
Siteman Cancer Center
St. Louis, Missouri, United States, 63110
United States, Nebraska
Nebraska Cancer Specialists
Omaha, Nebraska, United States, 68114
United States, South Carolina
MUSC Hollings Cancer Center
Charleston, South Carolina, United States, 29425 收起 <<
Terminated(Study terminated ea... 展开 >>rly prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.) 收起 <<
Terminated(Further data are no... 展开 >> longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings) 收起 <<
Terminated(Further data are no... 展开 >> longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings) 收起 <<
United States, California
... 展开 >>
Stanford University Medical Center
Not yet recruiting
Palo Alto, California, United States, 94305
Contact: Mark A Burbridge, MD 650-353-8484 markburb@stanford.edu
Contact: Richard A Jaffe, MD, PhD (650) 723-6411 rajaffe@stanford.edu
Principal Investigator: Mark A Burbridge, MD
Sub-Investigator: Richard A Jaffe, MD, PhD
Sub-Investigator: Jaime R Lopez, MD 收起 <<
United States, New York
... 展开 >>
SUNY Upstate Medical University
Not yet recruiting
Syracuse, New York, United States, 13210
Contact: Kristine Garcia, BS 315-464-5934
Contact: Dena Martin, BS 3154645262
Principal Investigator: Ajeet Gajra, MD FACP 收起 <<
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