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氟米龙醋酸酯 /Fluorometholone acetate {[allProObj[0].p_purity_real_show]}

货号:A103738

Fluorometholone acetate is a synthetic corticosteroid that is used to treat steroid responsive inflammatory conditions of the eye.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Fluorometholone acetate 化学结构 CAS号:3801-06-7
Fluorometholone acetate 化学结构
CAS号:3801-06-7
Fluorometholone acetate 3D分子结构
CAS号:3801-06-7
Fluorometholone acetate 化学结构 CAS号:3801-06-7
Fluorometholone acetate 3D分子结构 CAS号:3801-06-7
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Fluorometholone acetate 纯度/质量文件 产品仅供科研

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Fluorometholone acetate 生物活性

描述 Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis[3]. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[4].

Fluorometholone acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01448213 Fuchs' Dystrophy ... 展开 >> Bullous Keratopathy 收起 << Phase 2 Completed - United States, Indiana ... 展开 >> Price Vision Group Indianapolis, Indiana, United States, 46260 Germany University of Erlangen Erlangen, Germany 收起 <<
NCT03123614 Intraocular Pressure ... 展开 >> Corneal Opacity 收起 << Phase 4 Completed - United States, Utah ... 展开 >> Moran Eye Center - Midvalley Location Murray, Utah, United States, 84107 收起 <<
NCT01448213 - Completed - -

Fluorometholone acetate 参考文献

[1]Hata Y, Enaida H, et al. Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery. Graefes Arch Clin Exp Ophthalmol. 2007 Jul;245(7):1019-25.

[2]Stewart RH, Smith JP, Rosenthal AL. Ocular pressure response to fluorometholone acetate and dexamethasone sodium phosphate. Curr Eye Res. 1984 Jun;3(6):835-9.

[3]Kupferman A, Berrospi AR, Leibowitz HM. Fluorometholone acetate. A new ophthalmic derivative of fluorometholone. Arch Ophthalmol. 1982 Apr;100(4):640-1

[4]Alım Z, Kılınç N, İşgör MM, Şengül B, Beydemir Ş. Some Anti-Inflammatory Agents Inhibit Esterase Activities of Human Carbonic Anhydrase Isoforms I and II: An In Vitro Study. Chem Biol Drug Des. 2015 Oct;86(4):857-63

Fluorometholone acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.89mL

4.78mL

2.39mL

Fluorometholone acetate 技术信息

CAS号3801-06-7
分子式C24H31FO5
分子量 418.498
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(250.9 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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