产品说明书
Fluorometholone acetate
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同义名 : | - |
| CAS号 : | 3801-06-7 | |
| 货号 : | A103738 | |
| 分子式 : | C24H31FO5 | |
| 纯度 : | 98% | |
| 分子量 : | 418.498 | |
| MDL号 : | MFCD00866062 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(250.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Hourly topical administration of 0.1% fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis[3]. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01448213 | Fuchs' Dystrophy ... 展开 >> Bullous Keratopathy 收起 << | Phase 2 | Completed | - | United States, Indiana ... 展开 >> Price Vision Group Indianapolis, Indiana, United States, 46260 Germany University of Erlangen Erlangen, Germany 收起 << |
| NCT03123614 | Intraocular Pressure ... 展开 >> Corneal Opacity 收起 << | Phase 4 | Completed | - | United States, Utah ... 展开 >> Moran Eye Center - Midvalley Location Murray, Utah, United States, 84107 收起 << |
| NCT01448213 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.39mL 0.48mL 0.24mL |
11.95mL 2.39mL 1.19mL |
23.89mL 4.78mL 2.39mL |
| 参考文献 |
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