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醋酸氟轻松 /Fluocinolone Acetonide {[allProObj[0].p_purity_real_show]}

货号：A107277 同义名： 醋酸肤轻松 / Fluocinolone acetonide;Flucort-N

Fluocinolone acetonide, the acetonide form of fluocinolone, is a derivative of glucocorticoid and is used for the treatment of skin disorders.

Fluocinolone Acetonide 化学结构 CAS号：67-73-2
Fluocinolone Acetonide 化学结构
CAS号：67-73-2
Fluocinolone Acetonide 3D分子结构
CAS号：67-73-2
Fluocinolone Acetonide 化学结构 CAS号：67-73-2
Fluocinolone Acetonide 3D分子结构 CAS号：67-73-2
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Fluocinolone Acetonide 纯度/质量文件 产品仅供科研

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Fluocinolone Acetonide 生物活性

描述 Fluocinolone, a potent glucocorticoid receptor agonist, effectively prevents lipid accumulation and inflammation. It also promotes the proliferation of dental pulp cells (DPCs), suggesting a potential role in the repair of injured pulp tissues. Fluocinolone is being researched for its effectiveness in preventing chemotherapy-induced peripheral neuropathy, particularly associated with the use of Paclitaxel[1].[2].[3].[4].
体内研究

Fluocinolone (500 μg/kg, intraperitoneal injection, once daily for 2 weeks) inhibits the onset of significant peripheral neuropathy in a PTX-induced mouse model[3].
体外研究

Fluocinolone (0.1-50 μg/mL, 2 days) enhances survival in THP-1 foam cells[1].

Fluocinolone (0.1-50 μg/mL, 2 days) decreases the secretion of inflammatory cytokines and lowers cholesteryl ester buildup[1].

Fluocinolone (0.1-100 μmol/L, 24 h) enhances the proliferation of DPCs[2].

Fluocinolone (1-10 μmol/L, 7 days) stimulates the production of BSP, OCN, DSPP, and Wnt4, and increases the levels of Wnt4 and the dentin-specific marker dentin sialophosphoprotein[2].

Fluocinolone Acetonide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03345914 Dermatitis, Atopic Phase 3 Recruiting April 12, 2019 United States, Alabama ... 展开 >> Regeneron Investigational Site Recruiting Birmingham, Alabama, United States, 35209 United States, California Regneron Investigational Site Recruiting Bakersfield, California, United States, 93309 Regeneron Investigational Site Recruiting Long Beach, California, United States, 90808 Regeneron Investigational Site Recruiting Mission Viejo, California, United States, 92691 United States, Florida Regeneron Investigational Site Recruiting Coral Gables, Florida, United States, 33146 United States, Georgia Regeneron Investigational Site Recruiting Macon, Georgia, United States, 31217 Regeneron Investigational Site Recruiting Sandy Springs, Georgia, United States, 30328 United States, Maryland Regeneron Investigational Site Recruiting Rockville, Maryland, United States, 20850 United States, New York Regeneron Investigational Site Recruiting Forest Hills, New York, United States, 11375 Regeneron Investigational Site Recruiting New York, New York, United States, 10029 United States, Texas Regeneron Investigational Site Recruiting Bellaire, Texas, United States, 77401 Regeneron Investigational Site Recruiting San Antonio, Texas, United States, 78218 United States, Virginia Regeneron Investigational Site Recruiting Norfolk, Virginia, United States, 23502 Poland Regeneron Investigational Site Recruiting Białystok, Poland, 15-453 Regeneron Investigational Site Recruiting Katowice, Poland, 40-611 Regeneron Investigational Site Recruiting Katowice, Poland, 40-648 Regeneron Investigational Site Recruiting Warsaw, Poland, 01-142 Regeneron Investigational Site Recruiting Warsaw, Poland, 02-758 Regeneron Investigational Site Recruiting Warszawa, Poland, 01-817 Regeneron Investigational Site Recruiting Wrocław, Poland, 50-381 Regeneron Investigational Site Recruiting Świętokrzyskie, Poland, 27-400 收起 <<
NCT02260986 Atopic Dermatitis Phase 3 Completed - -
NCT01946386 Psoriasis Vulgaris Phase 1 Completed - France ... 展开 >> CPCAD, Centre de Pharmacologie Clinique Appliquée à la Dermatologie Nice, France, 06202 收起 <<

Fluocinolone Acetonide 参考文献

[1]Nguyen L T H, et al. The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures [J]. BioMed Research International, 2018, 2018.

[2]Liu Z, et al. Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells [J]. Journal of endodontics, 2013, 39(2): 217-222.

[3]Cetinkaya-Fisgin A, et al. Identification of fluocinolone acetonide to prevent paclitaxel‐induced peripheral neuropathy [J]. Journal of the Peripheral Nervous System, 2016, 21(3): 128-133.

[4]Nehmé A, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells [J]. BMC medical genomics, 2009, 2(1): 1-14.

Fluocinolone Acetonide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.05mL

2.21mL

1.11mL

22.10mL

4.42mL

2.21mL

Fluocinolone Acetonide 技术信息

CAS号67-73-2
分子式C24H30F2O6
分子量 452.488
别名 醋酸肤轻松 ;Fluocinolone acetonide;Flucort-N;Fluocinolone Acetonide, Synandone, Flucinar, Fluonid, Jellin, Sinalar;NSC 92339
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 30 mg/mL(66.3 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 8 mg/mL clear

PO 0.5% CMC-Na 30 mg/mL suspension

Tags: Fluocinolone Acetonide | Fluocinolone acetonide;Flucort-N;Fluocinolone Acetonide, Synandone, Flucinar, Fluonid, Jellin, Sinalar;NSC 92339 | 醋酸肤轻松 | Progesterone | Glucocorticoid | Glucocorticoid Receptor | AmBeed-信号通路专用抑制剂 | Fluocinolone Acetonide 纯度/质量文件 | Fluocinolone Acetonide 生物活性 | Fluocinolone Acetonide 临床数据 | Fluocinolone Acetonide 参考文献 | Fluocinolone Acetonide 实验方案 | Fluocinolone Acetonide 技术信息

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