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Fluocinolone Acetonide

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Chemical Structure| 67-73-2 同义名 : 醋酸肤轻松 ;Fluocinolone acetonide;Flucort-N;Fluocinolone Acetonide, Synandone, Flucinar, Fluonid, Jellin, Sinalar;NSC 92339
CAS号 : 67-73-2
货号 : A107277
分子式 : C24H30F2O6
纯度 : 98%
分子量 : 452.488
MDL号 : MFCD00010525
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(66.3 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 8 mg/mL clear

PO 0.5% CMC-Na 30 mg/mL suspension

生物活性
描述 Fluocinolone, a potent glucocorticoid receptor agonist, effectively prevents lipid accumulation and inflammation. It also promotes the proliferation of dental pulp cells (DPCs), suggesting a potential role in the repair of injured pulp tissues. Fluocinolone is being researched for its effectiveness in preventing chemotherapy-induced peripheral neuropathy, particularly associated with the use of Paclitaxel[1].[2].[3].[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03345914 Dermatitis, Atopic Phase 3 Recruiting April 12, 2019 United States, Alabama ... 展开 >> Regeneron Investigational Site Recruiting Birmingham, Alabama, United States, 35209 United States, California Regneron Investigational Site Recruiting Bakersfield, California, United States, 93309 Regeneron Investigational Site Recruiting Long Beach, California, United States, 90808 Regeneron Investigational Site Recruiting Mission Viejo, California, United States, 92691 United States, Florida Regeneron Investigational Site Recruiting Coral Gables, Florida, United States, 33146 United States, Georgia Regeneron Investigational Site Recruiting Macon, Georgia, United States, 31217 Regeneron Investigational Site Recruiting Sandy Springs, Georgia, United States, 30328 United States, Maryland Regeneron Investigational Site Recruiting Rockville, Maryland, United States, 20850 United States, New York Regeneron Investigational Site Recruiting Forest Hills, New York, United States, 11375 Regeneron Investigational Site Recruiting New York, New York, United States, 10029 United States, Texas Regeneron Investigational Site Recruiting Bellaire, Texas, United States, 77401 Regeneron Investigational Site Recruiting San Antonio, Texas, United States, 78218 United States, Virginia Regeneron Investigational Site Recruiting Norfolk, Virginia, United States, 23502 Poland Regeneron Investigational Site Recruiting Białystok, Poland, 15-453 Regeneron Investigational Site Recruiting Katowice, Poland, 40-611 Regeneron Investigational Site Recruiting Katowice, Poland, 40-648 Regeneron Investigational Site Recruiting Warsaw, Poland, 01-142 Regeneron Investigational Site Recruiting Warsaw, Poland, 02-758 Regeneron Investigational Site Recruiting Warszawa, Poland, 01-817 Regeneron Investigational Site Recruiting Wrocław, Poland, 50-381 Regeneron Investigational Site Recruiting Świętokrzyskie, Poland, 27-400 收起 <<
NCT02260986 Atopic Dermatitis Phase 3 Completed - -
NCT01946386 Psoriasis Vulgaris Phase 1 Completed - France ... 展开 >> CPCAD, Centre de Pharmacologie Clinique Appliquée à la Dermatologie Nice, France, 06202 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.05mL

2.21mL

1.11mL

22.10mL

4.42mL

2.21mL
参考文献

[1]Nguyen L T H, et al. The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures [J]. BioMed Research International, 2018, 2018.

[2]Liu Z, et al. Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells [J]. Journal of endodontics, 2013, 39(2): 217-222.

[3]Cetinkaya-Fisgin A, et al. Identification of fluocinolone acetonide to prevent paclitaxel‐induced peripheral neuropathy [J]. Journal of the Peripheral Nervous System, 2016, 21(3): 128-133.

[4]Nehmé A, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells [J]. BMC medical genomics, 2009, 2(1): 1-14.