非那雄胺 /Finasteride
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货号：A201116
同义名：
非那甾胺
/ MK-906
Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).
Finasteride 化学结构
Finasteride 3D分子结构
规格
价格
会员价
库存
数量
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Finasteride 纯度/质量文件 产品仅供科研
货号：A201116
标准纯度：
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产品说明书
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Finasteride 质控信息
Dutasteride
✔
98%
Finasteride
+++
5-α reductase, Ki: 10.2 nM
98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Finasteride 生物活性
靶点
描述
Steroid 5α-reductase (5αR) is the NADPH-dependent enzyme required for the conversion of testosterone (T) to dihydrotestosterone (DHT) [7] [8] [7] [9] [10] [11]
Finasteride 动物研究
Animal study
尿道下裂模型
动物：SD大鼠，雌雄皆有，SPF级, 体重: ~150 g。
给药：雌鼠受孕第8天灌胃非那雄胺，1周后成功制备尿道下裂模型。
Pharmacokinetics
Animal
Rats[6]
Dogs[6]
Monkeys[6]
Dose
5 mg/kg
10 mg/kg
10 mg/kg
Administration
p.o.
p.o.
p.o.
F
0.294
0.923
0.8
T1/2
1.7 h
5.1 h
6.6 h
Tmax
1 h
1.7 h
12 h
Cmax
0.30 μg/ml
2.93 μg/ml
0.92 μg/ml
AUC
0.94 μg·h/ml
37.7 μg·h/ml
13.9 μg·h/ml
Finasteride 参考文献
[1] Bologna M, Muzi P, et al. Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro. Urology. 1995 Feb;45(2):282-90.
[2] Azzolina B, Ellsworth K, et al. Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition. J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64.
[3] Soni KK, Shin YS, et al. Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway. Drug Des Devel Ther. 2017 Oct 11;11:2969-2979.
[4] Bowman CJ, Barlow NJ, et al. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003 Aug;74(2):393-406. Epub 2003 May 28.
[5] Frau R, Mosher LJ, et al. The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating. Psychoneuroendocrinology. 2016 Jan;63:59-67.
[6] Finasteride
[7] Azzolina B. Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition. J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64.
[8] Weisser H. In vitro inhibition of androstenedione 5alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol. 1998 Oct;67(1):49-55. doi: 10.1016/s0960-0760(98)00071-5.
[9] Bologna M. Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro. Urology. 1995 Feb;45(2):282-90.
[10] Wang LG. Down-regulation of prostate-specific antigen expression by finasteride through inhibition of complex formation between androgen receptor and steroid receptor-binding consensus in the promoter of the PSA gene in LNCaP cells. Cancer Res. 1997 Feb 15;57(4):714-9.
[11] Clark RL. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor. Teratology. 1990 Jul;42(1):91-100.
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Finasteride 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.68mL
0.54mL
0.27mL
13.42mL
2.68mL
1.34mL
26.84mL
5.37mL
2.68mL
Finasteride 技术信息
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