货号:A349742 同义名: BR-A-657;Kanarb
Fimasartan is an improved non-peptide angiotensin II receptor blocker used for the treatment of hypertension and heart failure, which enables higher potency and longer duration than losartan.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Fimasartan (BR-A-657) is an angiotensin receptor II antagonist. Fimasartan displaced angiotensin II (Ang II) from its specific binding sites to AT1 subtype receptors in membrane fractions of HEK-293 cells with an IC50 of 0.16 nM. In conscious rats, Fimasartan (0.01, 0.1, 1 mg/kg; intravenously) dose-dependently antagonized Ang II-induced pressor responses. Fimasartan dose-dependently decreased mean arterial pressure in furosemide-treated rats and renal hypertensive rats. Fimasartan given orally at 1 and 3 mg/kg reduced blood pressure in conscious renal hypertensive rats[2]. In addition, fimasartan down-regulates the expression of the iNOS (inducible nitric oxide synthase) in macrophages via NF-κB (nuclear factor-kappa B) and AP-1 (activator protein-1) inactivation[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03649646 | - | Recruiting | September 9, 2020 | Korea, Republic of ... 展开 >> Ajou University Hospital Recruiting Suwon, Korea, Republic of Contact: Seung-Jae Tahk 收起 << | |
NCT02394392 | - | Completed | - | Korea, Republic of ... 展开 >> Korea university Guro hospital Seoul, Korea, Republic of 收起 << | |
NCT03254914 | - | Recruiting | September 30, 2019 | Korea, Republic of ... 展开 >> Seoul national university hospital Recruiting Seoul, Korea, Republic of Contact: Hae-young Lee, MD 收起 << | |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.99mL 0.40mL 0.20mL |
9.97mL 1.99mL 1.00mL |
19.93mL 3.99mL 1.99mL |
CAS号 | 247257-48-3 |
分子式 | C27H31N7OS |
分子量 | 501.646 |
别名 | BR-A-657;Kanarb |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,2-8°C |
溶解度 |
DMSO: 50 mg/mL(99.67 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |