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非马沙坦 /Fimasartan {[allProObj[0].p_purity_real_show]}

货号:A349742 同义名: BR-A-657;Kanarb

Fimasartan is an improved non-peptide angiotensin II receptor blocker used for the treatment of hypertension and heart failure, which enables higher potency and longer duration than losartan.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Fimasartan 化学结构 CAS号:247257-48-3
Fimasartan 化学结构
CAS号:247257-48-3
Fimasartan 3D分子结构
CAS号:247257-48-3
Fimasartan 化学结构 CAS号:247257-48-3
Fimasartan 3D分子结构 CAS号:247257-48-3
规格 价格 会员价 库存 数量
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Fimasartan 纯度/质量文件 产品仅供科研

货号:A349742 标准纯度: {[allProObj[0].p_purity_real_show]}
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Fimasartan 生物活性

描述 Fimasartan (BR-A-657) is an angiotensin receptor II antagonist. Fimasartan displaced angiotensin II (Ang II) from its specific binding sites to AT1 subtype receptors in membrane fractions of HEK-293 cells with an IC50 of 0.16 nM. In conscious rats, Fimasartan (0.01, 0.1, 1 mg/kg; intravenously) dose-dependently antagonized Ang II-induced pressor responses. Fimasartan dose-dependently decreased mean arterial pressure in furosemide-treated rats and renal hypertensive rats. Fimasartan given orally at 1 and 3 mg/kg reduced blood pressure in conscious renal hypertensive rats[2]. In addition, fimasartan down-regulates the expression of the iNOS (inducible nitric oxide synthase) in macrophages via NF-κB (nuclear factor-kappa B) and AP-1 (activator protein-1) inactivation[3].

Fimasartan 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03649646 - Recruiting September 9, 2020 Korea, Republic of ... 展开 >> Ajou University Hospital Recruiting Suwon, Korea, Republic of Contact: Seung-Jae Tahk 收起 <<
NCT02394392 - Completed - Korea, Republic of ... 展开 >> Korea university Guro hospital Seoul, Korea, Republic of 收起 <<
NCT03254914 - Recruiting September 30, 2019 Korea, Republic of ... 展开 >> Seoul national university hospital Recruiting Seoul, Korea, Republic of Contact: Hae-young Lee, MD 收起 <<

Fimasartan 参考文献

[1]Ryu S, et al. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation. Biol Pharm Bull. 2013;36(3):467-74.

[2]Chi YH, Lee JH, Kim JH, Tan HK, Kim SL, Lee JY, Rim HK, Paik SH, Lee KT. Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist. Biol Pharm Bull. 2013;36(7):1208-15.

[3]Ryu S, Shin JS, Cho YW, Kim HK, Paik SH, Lee JH, Chi YH, Kim JH, Kim JH, Lee KT. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation. Biol Pharm Bull. 2013;36(3):467-74.

Fimasartan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.97mL

1.99mL

1.00mL

19.93mL

3.99mL

1.99mL

Fimasartan 技术信息

CAS号247257-48-3
分子式C27H31N7OS
分子量 501.646
别名 BR-A-657;Kanarb
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 50 mg/mL(99.67 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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