Fadrozole HCl specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively.
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Type
HazMat fee for 500 gram (Estimated)
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USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
The aromatase inhibitors have proven to be efficacious in the treatment of estrogen-dependent diseases. Fadrozole HCl is a potent, selective, orally active, nonsteroidal inhibitor of aromatase with an IC50 value of 6.4nM. It is approximately 1000 times more selective than aminoglutethimide in inhibiting aromatase. Fadrozole HCl inhibited the production of estrogen with an IC50 value of 0.03μM in hamster ovarian slices. In immature female rats, oral administration of fadrozole HCl inhibited aromatase-mediated androstenedione-induced uterine hypertrophy with an EC50 value of 0.03mg/kg. In female rats bearing DMBA-induced mammary tumors, oral administration of fadrozole HCl almost completely suppressed the appearance of new tumors and inhibited the growth of palpable tumors with an ED50 value of 0.1mg/kg/day. The maximal anti-tumor effect was observed at a dosage of 2mg/kg/day[3].
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