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FT113 {[allProObj[0].p_purity_real_show]}

货号:A1149113

FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme.

FT113 化学结构 CAS号:1630808-89-7
FT113 化学结构
CAS号:1630808-89-7
FT113 3D分子结构
CAS号:1630808-89-7
FT113 化学结构 CAS号:1630808-89-7
FT113 3D分子结构 CAS号:1630808-89-7
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FT113 纯度/质量文件 产品仅供科研

货号:A1149113 标准纯度: {[allProObj[0].p_purity_real_show]}
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FT113 生物活性

描述 The fatty acids are synthesized by a number of decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA. Fatty acid synthase is a multi-enzyme protein which is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH. FT113 is a novel potent inhibitor of fatty acid synthase (fasn) with IC50 of 213 nM, which also displays excellent cellular activity(Mv411 cell IC50=26nM) [1]. The pharmacokinetic properties of FT113 were assessed in mice, and FT113 showed no acute toxicity and provided excellent exposure when dosed orally at 5 mg/kg. Also upon oral dosing at 5 mg/kg in male Sprague-Dawley rats, FT113 displayed excellent exposure and bioavailability[1] .

FT113 参考文献

[1]Martin MW, Lancia DR Jr, Li H, Schiller SER, Toms AV, Wang Z, Bair KW, Castro J, Fessler S, Gotur D, Hubbs SE, Kauffman GS, Kershaw M, Luke GP, McKinnon C, Yao L, Lu W, Millan DS. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006. doi: 10.1016/j.bmcl.2019.02.012. Epub 2019 Feb 11. PMID: 30803804.

FT113 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.21mL

2.44mL

1.22mL

24.43mL

4.89mL

2.44mL

FT113 技术信息

CAS号1630808-89-7
分子式C22H20FN3O4
分子量 409.41
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 60 mg/mL(146.55 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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