艾塞那肽-4 /Exendin-4
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货号：A561110
同义名：
艾塞那肽-4
/ Exenatide
Exendin-4 是一种 GLP-1 受体激动剂，具有降血糖和促胰岛素分泌的作用。Exendin-4 主要用于糖尿病 和肥胖症的研究。
Exendin-4 化学结构
Exendin-4 3D分子结构
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Exendin-4 纯度/质量文件 产品仅供科研
货号：A561110
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Exendin-4 质控信息
Exendin-4 生物活性
描述
Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that has a capacity, when administered exogenously, to normalize blood glucose levels in type 2 diabetes mellitus. Exendin-4, a 39-amino acid (AA) peptide, is a long-acting agonist at the GLP-1 receptor with an IC50 value of 3.22 nM[3] [4] In vivo , ob/ob mice sustained a reduction in the net weight gained during exendin-4 treatment (10 μg/kg or 20 μg/kg for 60 days). Furthermore, serum glucose and hepatic steatosis was significantly reduced and insulin sensitivity was improved in exendin-4 treated ob/ob mice[5]
Exendin-4 参考文献
[1] Tsutsumi Y, Nomiyama T, et al. Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. PLoS One. 2015 Oct 6;10(10):e0139709.
[2] Zhou Y, He X, et al. Exendin-4 attenuates cardiac hypertrophy via AMPK/mTOR signaling pathway activation. Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):394-9.
[3] Doyle ME, Theodorakis MJ, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept . 2003 Jul 15;114(2-3):153-8
[4] Wei R, Ma S, Wang C, et al. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab . 2016 Jun 1;310(11):E947-57
[5] Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology . 2006 Jan;43(1):173-81
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Exendin-4 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
0.24mL
0.05mL
0.02mL
1.19mL
0.24mL
0.12mL
2.39mL
0.48mL
0.24mL
Exendin-4 技术信息
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