There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Cholesteryl ester transfer protein (CETP) is a glycoprotein that catalyzes the reciprocal neutral lipid exchange between HDL and apoB-containing lipoprotein particles. Evacetrapib is a potent and selective inhibitor of CETP that inhibits human recombinant CETP protein with an IC50 of 5.5nM and inhibits CETP activity in human plasma in vitro with an IC50 value of 26nM. In human ApoAI and CETP double transgenic mice, oral administration of evacetrapib at 30mg/kg resulted in 98.4%, 98.6%, and 18.4% inhibition of CETP activity at 4, 8 and 24h, respectively, after treatment. Evacetrapib at 1-30mg/kg dose-dependently inhibited CETP activity in vivo at 8h post-treatment. Treatment with evacetrapib (10 and 30mg/kg) also elevated the level of HDL-C in these animals.[3]
作用机制
Evacetrapib is a novel benzazepine-based CETP inhibitor that inhibits CETP activity both in vitro and in vivo without increasing blood pressure or inducing synthesis of aldosterone or cortisol.[3]
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HazMat Fee +
