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盐酸乙胺丁醇 /Ethambutol 2HCl {[allProObj[0].p_purity_real_show]}

货号：A991443 同义名： 乙胺丁醇二盐酸盐 / Emb dihydrochloride;Ethambutol (hydrochloride)

Ethambutol 2HCl is an antitubercular agent working by inhibiting the transfer of mycolic acids into the cell wall of the tubercle bacillus.

Ethambutol 2HCl 化学结构 CAS号：1070-11-7
Ethambutol 2HCl 化学结构
CAS号：1070-11-7
Ethambutol 2HCl 3D分子结构
CAS号：1070-11-7
Ethambutol 2HCl 化学结构 CAS号：1070-11-7
Ethambutol 2HCl 3D分子结构 CAS号：1070-11-7
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Ethambutol 2HCl 纯度/质量文件 产品仅供科研

货号：A991443 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Ethambutol 2HCl 生物活性

描述 Ethambutol dihydrochloride (Emb dihydrochloride) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Antibacterial Ethambutol dihydrochloride (Emb dihydrochloride) directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis[3]. Ethambutol dihydrochloride (Emb dihydrochloride) is potent against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro[4]. The % cell viability of A549 cells with all EDH (Ethambutol Dihydrochloride) formulations, pure EDH and chitosan carrier was higher than 80%, the calu-3 cell line had % viabilities of between 85 and 99%, and the % viability of NR8383 cells was between 81 and 100%. The pure EDH had a minimum inhibitory concentration (MIC) of 2 µg/mL while the EDH formulations had MIC values of less than 1 µg/mL when tested against M. bovis. The permeability of pure EDH across lipid bilayer was 48.7% after 2 h while in the EDH formulations it was enhanced to 71%[5].

Ethambutol 2HCl 参考文献

[1]Ethambutol. Tuberculosis (Edinb). 2008 Mar;88(2):102-5.

[2]Rastogi N, Labrousse V, et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol. 1996 Sep;33(3):167-75.

[3]Ethambutol. Tuberculosis (Edinb). 2008;88(2):102–105

[4]Rastogi N, Labrousse V, Goh KS. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol. 1996;33(3):167–175

[5]Ahmad MI, Nakpheng T, Srichana T. The safety of ethambutol dihydrochloride dry powder formulations containing chitosan for the possibility of treating lung tuberculosis. Inhal Toxicol. 2014;26(14):908–917

Ethambutol 2HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.61mL

0.72mL

0.36mL

18.04mL

3.61mL

1.80mL

36.07mL

7.21mL

3.61mL

Ethambutol 2HCl 技术信息

CAS号1070-11-7
分子式C10H26Cl2N2O2
分子量 277.232
别名 乙胺丁醇二盐酸盐 ;Emb dihydrochloride;Ethambutol (hydrochloride);EMB Hefa;EMB Fatol;Myambutol;Miambutol;OR063209;(+)-(S,S)-ethambutol dihydrochloride;(+)-ethambutol dihydrochloride;Ethambutol HCL;CHEBI:4878;Ethambutol Hydrochloride;CL40881;Ethambutol dihydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 105 mg/mL(378.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(180.35 mM)
动物实验配方

Tags: Ethambutol | 1070-11-7 | Emb | Induced Disease Models Products | Anti-infection | Endocrine and Metabolic Disease Models | Bacterial | Antibiotic | High Uric Acid Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ethambutol 2HCl 纯度/质量文件 | Ethambutol 2HCl 生物活性 | Ethambutol 2HCl 参考文献 | Ethambutol 2HCl 实验方案 | Ethambutol 2HCl 技术信息

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