产品说明书
Ethambutol 2HCl
 |
同义名 : | 乙胺丁醇二盐酸盐 ;Emb dihydrochloride;Ethambutol (hydrochloride);EMB Hefa;EMB Fatol;Myambutol;Miambutol;OR063209;(+)-(S,S)-ethambutol dihydrochloride;(+)-ethambutol dihydrochloride;Ethambutol HCL;CHEBI:4878;Ethambutol Hydrochloride;CL40881;Ethambutol dihydrochloride |
| CAS号 : | 1070-11-7 | |
| 货号 : | A991443 | |
| 分子式 : | C10H26Cl2N2O2 | |
| 纯度 : | 98% | |
| 分子量 : | 277.232 | |
| MDL号 : | MFCD00216025 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(378.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(180.35 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ethambutol dihydrochloride (Emb dihydrochloride) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Antibacterial Ethambutol dihydrochloride (Emb dihydrochloride) directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis[3]. Ethambutol dihydrochloride (Emb dihydrochloride) is potent against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro[4]. The % cell viability of A549 cells with all EDH (Ethambutol Dihydrochloride) formulations, pure EDH and chitosan carrier was higher than 80%, the calu-3 cell line had % viabilities of between 85 and 99%, and the % viability of NR8383 cells was between 81 and 100%. The pure EDH had a minimum inhibitory concentration (MIC) of 2 µg/mL while the EDH formulations had MIC values of less than 1 µg/mL when tested against M. bovis. The permeability of pure EDH across lipid bilayer was 48.7% after 2 h while in the EDH formulations it was enhanced to 71%[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.61mL 0.72mL 0.36mL |
18.04mL 3.61mL 1.80mL |
36.07mL 7.21mL 3.61mL |
| 参考文献 |
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[1]Ethambutol. Tuberculosis (Edinb). 2008 Mar;88(2):102-5. |