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首页 / 抑制剂/激动剂 / 内分泌学/激素 / ERR / Estrogen receptor modulator 1

Estrogen receptor modulator 1 {[allProObj[0].p_purity_real_show]}

货号：A251043 Ambeed 开学季，买赠积分，赢豪礼

Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα).

Estrogen receptor modulator 1 化学结构 CAS号：63676-22-2
Estrogen receptor modulator 1 化学结构
CAS号：63676-22-2
Estrogen receptor modulator 1 3D分子结构
CAS号：63676-22-2
Estrogen receptor modulator 1 化学结构 CAS号：63676-22-2
Estrogen receptor modulator 1 3D分子结构 CAS号：63676-22-2
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Estrogen receptor modulator 1 纯度/质量文件 产品仅供科研

货号：A251043 标准纯度： {[allProObj[0].p_purity_real_show]}
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Estrogen receptor modulator 1 生物活性

描述 A large proportion of breast cancer patients have a tumor expressing estrogen receptor (ER). Compounds that block the effects of estrogen in tumor tissues are considered as promising therapeutic options for breast cancer patients. Estrogen receptor modulator 1 is a selective and orally active estrogen receptor modulator with a pIC50 of 0.46[1]. Estrogen receptor modulator 1 at a concentration of 100 nM stimulated the proliferation of T47D:A18/neo cells compared to the control group. The incubation with 100 nM estrogen receptor modulator 1 also increased colony formation in T47D:A18/neo cells, but prevented T47D:A18/PKCα and T47D:A18-TAM1 colony formation. Estrogen receptor modulator 1 at 100 nM also induced apoptosis and inhibited growth of MCF-7:5C cells. In athymic mice inoculated with T47D:A18/PKCα cells, oral administration with estrogen receptor modulator 1 (1.5 mg/day) for two weeks significantly reduced tumor volume compared to the non-treated group. Daily administration of estrogen receptor modulator 1 (1.5 mg/day) for two weeks also resulted in significant tumor regression in mice with T47D:A18-TAM1 xenograft[2].

Estrogen receptor modulator 1 参考文献

[1]Brogi S, Papazafiri P, Roussis V, Tafi A. 3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors. Eur J Med Chem. 2013;67:344-351. doi:10.1016/j.ejmech.2013.06.048

[2]Molloy ME, White BE, Gherezghiher T, et al. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2014;13(11):2515-2526. doi:10.1158/1535-7163.MCT-14-0319

Estrogen receptor modulator 1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.13mL

0.83mL

0.41mL

20.64mL

4.13mL

2.06mL

41.27mL

8.25mL

4.13mL

Estrogen receptor modulator 1 技术信息

CAS号63676-22-2
分子式C14H10O2S
分子量 242.293
别名
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(433.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Estrogen receptor modulator 1 | 63676-22-2 | Estrogen receptor modulator1 | Estrogen receptor modulator-1 | Estrogen Receptor Modulator | Vitamin D Related/Nuclear Receptor | Estrogen Receptor/ERR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Estrogen receptor modulator 1 纯度/质量文件 | Estrogen receptor modulator 1 生物活性 | Estrogen receptor modulator 1 参考文献 | Estrogen receptor modulator 1 实验方案 | Estrogen receptor modulator 1 技术信息

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