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红霉素 /Erythromycin {[allProObj[0].p_purity_real_show]}

货号:A199997 同义名: NSC 55929;E-Mycin

Erythromycin是一种抗生素,广泛用于治疗多种细菌感染。

Erythromycin 化学结构 CAS号:114-07-8
Erythromycin 化学结构
CAS号:114-07-8
Erythromycin 3D分子结构
CAS号:114-07-8
Erythromycin 化学结构 CAS号:114-07-8
Erythromycin 3D分子结构 CAS号:114-07-8
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Erythromycin 纯度/质量文件 产品仅供科研

货号:A199997 标准纯度: {[allProObj[0].p_purity_real_show]}
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Erythromycin 生物活性

描述 Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity[3]. Erythromycin inhibited growth of P. falciparum with IC50 and IC90 values of 58.2 ± 7.7 microM and 104.0 ± 10.8 microM, respectively. Combinations of chloroquine with erythromycin showed synergistic effects against parasite growth in vitro[4]. The most common side effect of erythromycin is gastrointestinal intolerance, which appears to be related to disruption of intestinal motility[5]. First generation derivatives such as 2'-esters and acid-addition salts significantly improved the chemical stability and oral bioavailability of erythromycin[6].

Erythromycin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02757534 Gastroparesis Phase 2 Enrolling by invitation December 2020 United States, Iowa ... 展开 >> University of Iowa Iowa City, Iowa, United States, 52242 收起 <<
NCT01173133 - Unknown December 2010 United States, California ... 展开 >> Mills Penisula Hospital Recruiting Burlingame, California, United States, 94010-3282 Contact: John Griffin, MD    650-348-1503       Principal Investigator: John Griffin, MD 收起 <<
NCT01424254 Gastrointestinal Bleeding Phase 3 Completed - Canada, Quebec ... 展开 >> Montreal General Hospital Montreal, Quebec, Canada, H3G1A4 收起 <<

Erythromycin 参考文献

[1]Peeters T, Matthijs G, et al. Erythromycin is a motilin receptor agonist. Am J Physiol. 1989 Sep;257(3 Pt 1):G470-4.

[2]McCormack WM, George H, et al. Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother. 1977 Nov;12(5):630-5.

[3]Brittain DC. Erythromycin. Med Clin North Am. 1987;71(6):1147–1154

[4]Nakornchai S, Konthiang P. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006;100(3):185–191

[5]Nakornchai S, Konthiang P. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006;100(3):185–191

[6]Nakornchai S, Konthiang P. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006;100(3):185–191

Erythromycin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.36mL

0.27mL

0.14mL

6.81mL

1.36mL

0.68mL

13.63mL

2.73mL

1.36mL

Erythromycin 技术信息

CAS号114-07-8
分子式C37H67NO13
分子量 733.927
别名 NSC 55929;E-Mycin;Eryc-250;Eryc-125;HSDB 3074
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 105 mg/mL(143.07 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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