首页
/
/
/
/
Enalaprilat Dihydrate
依那普利拉水合物 /Enalaprilat Dihydrate
{[allProObj[0].p_purity_real_show]}
货号：A502548
同义名：
依那普利拉二水合物
/ MK-422;Enalaprilat (hydrate)
Enalaprilat Dihydrate 是 Enalapril 的活性代谢物，是一种有效、竞争性和长效的 ACE 抑制剂，IC50 值为 1.94 nM，常用于高血压的研究和治疗。
Enalaprilat Dihydrate 化学结构
Enalaprilat Dihydrate 3D分子结构
规格
价格
会员价
库存
数量
{[ item.pr_size ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}
{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}
{[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}
{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}
{[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]}
{[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}
现货
咨询
-
+
Enalaprilat Dihydrate 纯度/质量文件 产品仅供科研
货号：A502548
标准纯度：
{[allProObj[0].p_purity_real_show]}
产品说明书
全球学术期刊中引用的产品
• JMC , 2024. Ambeed. A918471 ,
A995972
]
• Anal. Chem. , 2024, 96(50): 19947-19954. Ambeed. A261947 ,
A1165388
]
• ACS Biomater. Sci. Eng. , 2024. Ambeed. A220462
]
• ACS Biomater. Sci. Eng. , 2024. Ambeed. A165235 ,
A110205
]
• Pharmaceutics , 2024, 16(12): 1546. Ambeed. A272538 ,
A187261 ,
A691302 ,
A506702
]
更多 >
Enalaprilat Dihydrate 质控信息
Enalaprilat Dihydrate 生物活性
靶点
描述
Enalaprilat dihydrate (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. The ACE inhibitors generally had higher affinity for the bradykinin than the angiotensin I binding sites. Perindoprilat had the highest selectivity for bradykinin versus angiotensin I binding sites, and enalaprilat has the lowest[3] [4] [5] [6]
Enalaprilat Dihydrate 参考文献
[1] Zou K, Maeda T, et al. Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme. J Biol Chem. 2009 Nov 13;284(46):31914-20.
[2] Ceconi C, Francolini G, et al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. Epub 2007 Aug 3.
[3] Ceconi C, Francolini G, Olivares A, Comini L, Bachetti T, Ferrari R. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6
[4] van Eickels M, Vetter H, Grohé C. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6
[5] Schumacher J, Puchakayala MR, Binkowski K, Eichler W, Dendorfer A, Klotz KF. Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats. Br J Anaesth. 2006 Apr;96(4):437-43
[6] Mangiacapra F, Peace AJ, Di Serafino L, Pyxaras SA, Bartunek J, Wyffels E, Heyndrickx GR, Wijns W, De Bruyne B, Barbato E. Intracoronary EnalaPrilat to Reduce MICROvascular Damage During Percutaneous Coronary Intervention (ProMicro) study. J Am Coll Cardiol. 2013 Feb 12;61(6):615-21
展开
Enalaprilat Dihydrate 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.60mL
0.52mL
0.26mL
13.01mL
2.60mL
1.30mL
26.01mL
5.20mL
2.60mL
Enalaprilat Dihydrate 技术信息
搜索
