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Enalaprilat Dihydrate
依那普利拉水合物 /Enalaprilat Dihydrate
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货号：A502548
同义名：
依那普利拉二水合物
/ MK-422;Enalaprilat (hydrate)
Enalaprilat is the first dicarboxylate-containing ACE inhibitor with IC50 of 1.94 nM, which is the active metabolite of enalapril.
Enalaprilat Dihydrate 化学结构
Enalaprilat Dihydrate 3D分子结构
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Enalaprilat Dihydrate 纯度/质量文件 产品仅供科研
货号：A502548
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Enalaprilat Dihydrate 质控信息
Enalaprilat Dihydrate 生物活性
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描述
Enalaprilat dihydrate (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. The ACE inhibitors generally had higher affinity for the bradykinin than the angiotensin I binding sites. Perindoprilat had the highest selectivity for bradykinin versus angiotensin I binding sites, and enalaprilat has the lowest[3] [4] [5] [6]
Enalaprilat Dihydrate 参考文献
[1] Zou K, Maeda T, et al. Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme. J Biol Chem. 2009 Nov 13;284(46):31914-20.
[2] Ceconi C, Francolini G, et al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. Epub 2007 Aug 3.
[3] Ceconi C, Francolini G, Olivares A, Comini L, Bachetti T, Ferrari R. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6
[4] van Eickels M, Vetter H, Grohé C. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6
[5] Schumacher J, Puchakayala MR, Binkowski K, Eichler W, Dendorfer A, Klotz KF. Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats. Br J Anaesth. 2006 Apr;96(4):437-43
[6] Mangiacapra F, Peace AJ, Di Serafino L, Pyxaras SA, Bartunek J, Wyffels E, Heyndrickx GR, Wijns W, De Bruyne B, Barbato E. Intracoronary EnalaPrilat to Reduce MICROvascular Damage During Percutaneous Coronary Intervention (ProMicro) study. J Am Coll Cardiol. 2013 Feb 12;61(6):615-21
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Enalaprilat Dihydrate 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.60mL
0.52mL
0.26mL
13.01mL
2.60mL
1.30mL
26.01mL
5.20mL
2.60mL
Enalaprilat Dihydrate 技术信息
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