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首页 / 抑制剂/激动剂 / 免疫/炎症 / 血小板生成素受体 / Eltrombopag Olamine

艾曲波帕乙醇胺盐 /Eltrombopag Olamine {[allProObj[0].p_purity_real_show]}

货号：A759657 同义名： 艾曲泊帕乙醇胺盐 / Eltrombopag diethanolamine salt;SB-497115GR

Eltrombopag olamine is an orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.

Eltrombopag Olamine 化学结构 CAS号：496775-62-3
Eltrombopag Olamine 化学结构
CAS号：496775-62-3
Eltrombopag Olamine 3D分子结构
CAS号：496775-62-3
Eltrombopag Olamine 化学结构 CAS号：496775-62-3
Eltrombopag Olamine 3D分子结构 CAS号：496775-62-3
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Eltrombopag Olamine 纯度/质量文件 产品仅供科研

货号：A759657 标准纯度： {[allProObj[0].p_purity_real_show]}
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Eltrombopag Olamine 生物活性

描述 Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia and the research of cardiovascular[1].[2].[3].[4].[5].
体内研究

Eltrombopag Olamine, administered orally at a dose of 10 mg/kg once daily for five days, is well tolerated in chimpanzees[1].

Moreover, when administered intraperitoneally at a dosage of 17.6 mg/kg once daily for two days, Eltrombopag Olamine significantly reduces the mean S. aureus counts in a mouse model of nasal infection[3].

Eltrombopag Olamine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01830660 Healthy Phase 1 Completed - China, Sichuan ... 展开 >> West China Hospital, Sichuan University Chengdu, Sichuan, China 收起 <<
NCT02158936 Thrombocytopaenia Phase 3 Terminated - -
NCT01957176 Thrombocytopaenia Phase 4 Active, not recruiting January 1, 2024 Argentina ... 展开 >> Novartis Investigative Site La Plata, Buenos Aires, Argentina, B1900AXI Belgium Novartis Investigative Site Leuven, Belgium, 3000 China Novartis Investigative Site Shanghai, China, 200025 France Novartis Investigative Site Paris Cedex 12, France, 75571 Greece Novartis Investigative Site Athens, Greece, 11527 Novartis Investigative Site Heraklion, Crete, Greece, 71201 Hong Kong Novartis Investigative Site Shatin, Hong Kong Hungary Novartis Investigative Site Debrecen, Hungary, 4012 Ireland Novartis Investigative Site Tullamore, Ireland Israel Novartis Investigative Site Tel Aviv, Israel, 64239 Korea, Republic of Novartis Investigative Site Seoul, Korea, Republic of, 136-705 Netherlands Novartis Investigative Site Amsterdam, Netherlands, 1081 HV Peru Novartis Investigative Site San Isidro, Lima, Peru, Lima 27 Poland Novartis Investigative Site Chorzow, Poland, 41-500 Romania Novartis Investigative Site Bucharest, Romania, 022328 Tunisia Novartis Investigative Site Montfleury, Tunisia, 1008 Novartis Investigative Site Sousse, Tunisia, 4000 收起 <<

Eltrombopag Olamine 参考文献

[1]Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30.

[2]Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93.

[3]Lee H, et al. Repurposing Eltrombopag for Multidrug Resistant Staphylococcus aureus Infections. Antibiotics (Basel). 2021 Nov 9;10(11):1372.

[4]Juan Zhu, et al. Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms. Curr Microbiol. 2021 Feb 21.

[5]Kurokawa T, et al. The Eltrombopag antitumor effect on hepatocellular carcinoma. Int J Oncol. 2015 Nov;47(5):1696-702.

Eltrombopag Olamine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.86mL

1.77mL

0.89mL

17.71mL

3.54mL

1.77mL

Eltrombopag Olamine 技术信息

CAS号496775-62-3
分子式C29H36N6O6
分子量 564.633
别名 艾曲泊帕乙醇胺盐 ;Eltrombopag diethanolamine salt;SB-497115GR;SB497115，SB-497115-GR
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 50 mg/mL(88.55 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Eltrombopag Olamine | Eltrombopag diethanolamine salt;SB-497115GR;SB497115，SB-497115-GR | 艾曲泊帕乙醇胺盐 | Thrombopoietin Receptor | AmBeed-信号通路专用抑制剂 | Eltrombopag Olamine 纯度/质量文件 | Eltrombopag Olamine 生物活性 | Eltrombopag Olamine 临床数据 | Eltrombopag Olamine 参考文献 | Eltrombopag Olamine 实验方案 | Eltrombopag Olamine 技术信息

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