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EBV lytic cycle inducer-1 {[allProObj[0].p_purity_real_show]}

货号:A2476872

EBV lytic cycle inducer-1是一种类似铁螯合物的化合物,能与 HDAC 抑制剂 Romidespin 和 SAHA 协同诱导 EBV 裂解周期,并通过激活 ERK1/2-自噬轴重新激活 EBV 裂解周期。

EBV lytic cycle inducer-1 化学结构 CAS号:394668-43-0
EBV lytic cycle inducer-1 化学结构
CAS号:394668-43-0
EBV lytic cycle inducer-1 3D分子结构
CAS号:394668-43-0
EBV lytic cycle inducer-1 化学结构 CAS号:394668-43-0
EBV lytic cycle inducer-1 3D分子结构 CAS号:394668-43-0
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EBV lytic cycle inducer-1 纯度/质量文件 产品仅供科研

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EBV lytic cycle inducer-1 生物活性

描述 Epstein-Barr virus (EBV) lytic cycle inducer-1, Dp44mT, is a compound with iron-chelating properties. It collaborates with HDAC inhibitors such as Romidespin and SAHA to induce the EBV lytic cycle. Dp44mT reactivates the EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].
体外研究

Dp44mT (at concentrations ranging from 0 to 80 μM; for 48 hours) induces the lytic cycle in a manner dependent on the cell line, exhibiting higher toxicity in AGS-BX1 compared to AGS[1].

Dp44mT induces the lytic cycle in a time-dependent manner when administered at a concentration of 10 μM over a period of 0 to 72 hours[1].

At concentrations ranging from 1.25 to 2.5 μM for 24 hours, Dp44mT collaborates with HDAC inhibitor Romidespin and SAHA to induce the EBV lytic cycle[1].

Exposure to 20 μM of Dp44mT for 48 hours triggers the EBV lytic cycle through the induction of the ERK-autophagy axis[2].

EBV lytic cycle inducer-1 参考文献

[1]Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994.

[2]Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.

EBV lytic cycle inducer-1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.43mL

6.29mL

3.14mL

EBV lytic cycle inducer-1 技术信息

CAS号394668-43-0
分子式C14H12BrN3O
分子量 318.169
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 12 mg/mL(37.72 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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