EBV lytic cycle inducer-1是一种类似铁螯合物的化合物,能与 HDAC 抑制剂 Romidespin 和 SAHA 协同诱导 EBV 裂解周期,并通过激活 ERK1/2-自噬轴重新激活 EBV 裂解周期。
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描述 | Epstein-Barr virus (EBV) lytic cycle inducer-1, Dp44mT, is a compound with iron-chelating properties. It collaborates with HDAC inhibitors such as Romidespin and SAHA to induce the EBV lytic cycle. Dp44mT reactivates the EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2]. |
体外研究 | Dp44mT (at concentrations ranging from 0 to 80 μM; for 48 hours) induces the lytic cycle in a manner dependent on the cell line, exhibiting higher toxicity in AGS-BX1 compared to AGS[1]. Dp44mT induces the lytic cycle in a time-dependent manner when administered at a concentration of 10 μM over a period of 0 to 72 hours[1]. At concentrations ranging from 1.25 to 2.5 μM for 24 hours, Dp44mT collaborates with HDAC inhibitor Romidespin and SAHA to induce the EBV lytic cycle[1]. Exposure to 20 μM of Dp44mT for 48 hours triggers the EBV lytic cycle through the induction of the ERK-autophagy axis[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.14mL 0.63mL 0.31mL |
15.71mL 3.14mL 1.57mL |
31.43mL 6.29mL 3.14mL |
CAS号 | 394668-43-0 |
分子式 | C14H12BrN3O |
分子量 | 318.169 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
DMSO: 12 mg/mL(37.72 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |