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EBV lytic cycle inducer-1

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Chemical Structure| 394668-43-0 同义名 : -
CAS号 : 394668-43-0
货号 : A2476872
分子式 : C14H12BrN3O
纯度 : 95%
分子量 : 318.169
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(37.72 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Epstein-Barr virus (EBV) lytic cycle inducer-1, Dp44mT, is a compound with iron-chelating properties. It collaborates with HDAC inhibitors such as Romidespin and SAHA to induce the EBV lytic cycle. Dp44mT reactivates the EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.43mL

6.29mL

3.14mL
参考文献

[1]Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994.

[2]Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.