产品说明书

Duloxetine

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Chemical Structure| 116539-59-4 同义名 : (S)-Duloxetine;LY248686
CAS号 : 116539-59-4
货号 : A683411
分子式 : C18H19NOS
纯度 : 98+%
分子量 : 297.415
MDL号 : MFCD06801358
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
靶点
  • 5-HT

描述 Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00190645 Stress Urinary Incontinence Phase 3 Completed - United States, Colorado ... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician Denver, Colorado, United States, 80220 Canada, Ontario For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559,1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician Oakville, Ontario, Canada, L6H3P1 收起 <<
NCT00387413 Hyperalgesia Phase 1 Completed - United Kingdom ... 展开 >> GSK Investigational Site Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ 收起 <<
NCT00945945 Osteoarthritis Knee Pain Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.81mL

3.36mL

1.68mL

33.62mL

6.72mL

3.36mL

参考文献

[1]De Berardis D, Conti CM, et al. The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol. 2010 Apr-Jun;23(2):417-22.

[2]Wang SY, Calderon J, et al. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65.