Drospirenone | 屈螺酮，二氢螺利酮 | Dihydrospirorenone | Progesterone Receptor Agonist

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屈螺酮 /Drospirenone {[allProObj[0].p_purity_real_show]}

货号：A689592 同义名： 屈螺酮，二氢螺利酮 / Dihydrospirorenone;ZK 30595

Drospirenone是一种合成孕激素，属于螺内酯的类似物，主要用于激素替代疗法及相关研究。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Drospirenone 化学结构
CAS号：67392-87-4

Drospirenone 3D分子结构
CAS号：67392-87-4

规格	价格	会员价	库存	数量
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Drospirenone 纯度/质量文件产品仅供科研

货号：A689592 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

Drospirenone 生物活性

靶点

Progesterone receptor

描述

Drospirenone is a novel progestin under clinical development that is similar to the natural hormone progesterone, combining potent progestogenic with antimineralocorticoid and antiandrogenic activities. Drospirenone displayed high affinity to PR (progesterone receptor) and MR (mineralocorticoid receptor) and low binding to AR (androgen receptor), similar to progesterone. Drospirenone showed considerable antimineralocorticoid activity and weak mineralocorticoid activity^[3]. Drospirenone acts on the renin-angiotensin-aldosterone system (RAAS), which prevents excessive sodium loss and regulates blood pressure. The antialdosterone properties exhibited by drospirenone promote sodium excretion and prevent water retention, conferring potential blood pressure benefits^[4]. The lowest effective dose of drospirenone for reduction in BP (blood pressure) is 2mg, a dose that is also protective of the uterus in women treated with estrogen therapy. In addition to effectively relieving menopausal symptoms and lowering BP, drospirenone reduces bodyweight and lipoprotein concentrations^[5]. The combination of 17beta-estradiol with drospirenone offers a safe and effective medication for decreasing bone turnover and preventing postmenopausal bone loss in postmenopausal women^[6].

Drospirenone 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00185328	Postmenopause	Phase 4	Completed	-	-
NCT00442689	Polycystic Ovary Syndrome ... 展开 >> Metabolic Syndrome 收起 <<	Not Applicable	Completed	-	United States, Illinois ... 展开 >> Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 收起 <<
NCT00442689	-		Completed	-	-

Drospirenone 参考文献

[1]Fuhrmann U, Krattenmacher R, et al. The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception. 1996 Oct;54(4):243-51.

[2]Muhn P, Krattenmacher R, et al. Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models. Contraception. 1995 Feb;51(2):99-110.

[3]Fuhrmann U, Krattenmacher R, Slater EP, Fritzemeier KH. The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception. 1996 Oct;54(4):243-51

[4]Genazzani AR, Mannella P, Simoncini T. Drospirenone and its antialdosterone properties. Climacteric. 2007 Feb;10 Suppl 1:11-8

[5]Mallareddy M, Hanes V, White WB. Drospirenone, a new progestogen, for postmenopausal women with hypertension. Drugs Aging. 2007;24(6):453-66

[6]Christiansen C. Effects of drospirenone/estrogen combinations on bone metabolism. Climacteric. 2005 Oct;8 Suppl 3:35-41

Drospirenone 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.64mL

2.73mL

1.36mL

27.29mL

5.46mL

2.73mL

Drospirenone 技术信息

CAS号	67392-87-4
分子式	C₂₄H₃₀O₃
分子量	366.493

别名	屈螺酮，二氢螺利酮 ;Dihydrospirorenone;ZK 30595;Dehydrospirorenone;Drospirenonum;Drospirenona;67392-87-4;1,2-dihydro Spirorenone;ZK 3059
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00185328	Postmenopause	Phase 4	Completed	-	-
NCT00442689	Polycystic Ovary Syndrome ... 展开 >> Metabolic Syndrome 收起 <<	Not Applicable	Completed	-	United States, Illinois ... 展开 >> Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 收起 <<
NCT00442689	-		Completed	-	-
NCT03075956	Contraception ... 展开 >> Menopause 收起 <<	Phase 1	Completed	-	Bulgaria ... 展开 >> COMAC Sofia, Bulgaria 收起 <<
NCT01319500	-		Completed	-	-
NCT00651846	Healthy	Phase 4	Completed	-	Germany ... 展开 >> Berlin, Germany, 10115 收起 <<
NCT01319500	-		Completed	-	Germany ... 展开 >> Center for Epidemiology and Health Research Berlin Berlin, Germany, 10115 收起 <<
NCT03126773	-		Recruiting	April 30, 2020	Russian Federation ... 展开 >> Many locations Recruiting Multiple Locations, Russian Federation 收起 <<
NCT00214903	-		Completed	-	-
NCT00948402	Polycystic Ovarian Syndrome ... 展开 >> Insulin Sensitivity 收起 <<	Phase 3	Completed	-	-
NCT01852786	-		Unknown	February 2016	Lithuania ... 展开 >> Lithuanian University of Health Sciences Kaunas, Lithuania, LT- 50009 收起 <<
NCT00651599	Vasomotor Symptoms	Phase 3	Completed	-	Korea, Republic of ... 展开 >> Seoul, Korea, Republic of, 110-744 Seoul, Korea, Republic of, 135-710 Seoul, Korea, Republic of, 138-736 Seoul, Korea, Republic of 收起 <<
NCT00593294	Polycystic Ovary Syndrome	Phase 4	Completed	-	Italy ... 展开 >> Department of Molecular and Clinical Endocrinology and Oncology, University "Federico II" Naples, Italy, 80131 收起 <<
NCT01805817	Contraceptive Methods Comparis... 展开 >>on 收起 <<	Phase 4	Unknown	-	Turkey ... 展开 >> Istanbul Training and Research Hospital Recruiting Istanbul, Turkey, 34098 Contact: Cihangir Uzunçakmak, M.D. 0090 505 4505808 cuzuncakmak@gmail.com Principal Investigator: Cihangir Uzuncakmak, M.D. 收起 <<
NCT00214903	-		Completed	-	Germany ... 展开 >> Center for Epidemiology and Health Research Berlin, Germany, 10115 收起 <<
NCT02237131	Dysmenorrhea ... 展开 >>Pelvic Pain Dyspareunia Endometrioma 收起 <<	Phase 4	Unknown	December 2015	Greece ... 展开 >> Aretaieion Hospital Recruiting Athens, Greece Contact: Olga B Triantafyllidou, M.D, Msc +306944963506 triantafyllidouolga@yahoo.com Principal Investigator: Nikos Vlahos, AssProfessor 收起 <<
NCT00785317	Hormone Replacement Therapy	Phase 4	Unknown	April 2010	Sweden ... 展开 >> Karolinska University Hospital Recruiting Stockholm, Sweden Principal Investigator: Eva Lundström 收起 <<
NCT02710708	Contraception	Phase 4	Completed	-	-
NCT00089414	-		Terminated(Informed by manufac... 展开 >>turer that CDB-2914 crosses blood-brain barrier invalidating Arm #3 of protocol.) 收起 <<	-	-
NCT03418363	Contraceptive Usage ... 展开 >> Coagulation 收起 <<	Phase 2	Active, not recruiting	June 2019	United States, Oregon ... 展开 >> Oregon Health & Science University Portland, Oregon, United States, 97239 收起 <<
NCT00089414	Premenstrual Syndrome ... 展开 >> PMS Premenstrual Dysphoric Disorder PMDD Depression 收起 <<	Phase 2	Terminated(Informed by manufac... 展开 >>turer that CDB-2914 crosses blood-brain barrier invalidating Arm #3 of protocol.) 收起 <<	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT02089620	Premenstrual Syndrome	Phase 3	Completed	-	Egypt ... 展开 >> Beni-Suef University Beni-Suef, Egypt 收起 <<
NCT01291004	Follicle Development ... 展开 >> Ovarian Follicle Follicle Count Follicle Size Oral Contraceptive 收起 <<	Phase 1	Completed	-	United States, Pennsylvania ... 展开 >> Teva Investigational Site Philadelphia, Pennsylvania, United States, 19114 United States, Washington Teva Investigational Site Seattle, Washington, United States, 98105 收起 <<
NCT02562053	Premenstrual Syndrome	Phase 3	Unknown	September 2017	Egypt ... 展开 >> BeniSuef University hospitals Recruiting BeniSuef, Egypt Contact: Nesreen AA Shehata, MD +2001227866337 nesoomar@yahoo.com Cairo University Hospitals Recruiting Cairo, Egypt Contact: AbdelGany MA Hassan, MRCOG, MD 00217801604 abdelgany2@gmail.com Principal Investigator: AbdelGany MA Hassan, MRCOG, MD 收起 <<
NCT00676065	-		Completed	-	Germany ... 展开 >> Center for Epidemiology and Health Research Berlin, Germany 收起 <<
NCT00676065	-		Completed	-	-
NCT02488538	Premenstrual Syndrome	Phase 3	Recruiting	-	Egypt ... 展开 >> BeniSuef University hospitals Recruiting BeniSuef, Egypt Contact: Nesreen AA Shehata, MD +2001227866337 nesoomar@yahoo.com Principal Investigator: Nesreen AA Shehata, MD Cairo University Hospitals Recruiting Cairo, Egypt Contact: AbdelGany MA Hassan, MRCOG, MD 00217801604 abdelgany2@gmail.com Principal Investigator: AbdelGany MA Hassan, MRCOG, MD 收起 <<
NCT01266408	-		Recruiting	December 2025	Germany ... 展开 >> Center for Epidemiology and Health Research Recruiting Berlin, Germany, 10115 Contact: Suzanne Reed, MSc, PhD +49 30 945 101 63 reed@zeg-berlin.de Contact: Klaas Heinemann, PhD, MD, MBA +49 30 945 101 24 k.heinemann@zeg-berlin.de Principal Investigator: Juergen C Dinger, PhD, MD 收起 <<
NCT00567164	Contraception ... 展开 >> Ovulation Inhibition Contraceptives, Oral 收起 <<	Phase 3	Completed	-	-
NCT00567164	-		Completed	-	-
NCT00824187	Premenstrual Dysphoric Disorde... 展开 >>r ( PMDD) 收起 <<	Phase 3	Completed	-	China, Guangdong ... 展开 >> Guangzhou, Guangdong, China, 510405 Guangzhou, Guangdong, China, 510630 China, Hubei Wuhan, Hubei, China, 430060 China, Hunan Changsha, Hunan, China, 410011 China, Jiangsu Nanjing, Jiangsu, China, 210029 China, Liaoning Dalian, Liaoning, China, 116011 China, Shandong Jinan, Shandong, China, 250012 China, Shanxi Xi'an, Shanxi, China, 710032 Xi'an, Shanxi, China, 710061 China, Sichuan Chengdu, Sichuan, China, 610041 China, Yunnan Kunming, Yunnan, China, 650032 China, Zhejiang Hangzhou, Zhejiang, China, 310003 China Beijing, China, 100050 Beijing, China, 100191 Beijing, China, 100853 Tianjin, China, 300193 收起 <<
NCT03353857	Biological Availability	Phase 1	Active, not recruiting	December 18, 2018	Germany ... 展开 >> CRS Clinical-Research-Services Mannheim GmbH Mannheim, Baden-Württemberg, Germany, 68167 CRS Clinical-Research-Services Mönchengladbach GmbH Mönchengladbach, Nordrhein-Westfalen, Germany, 41061 收起 <<
NCT00185419	Contraception	Phase 3	Completed	-	China ... 展开 >> ask Contact, China 收起 <<
NCT01076582	Oral Contraceptive	Phase 3	Completed	-	-
NCT02855294	Joint Stabilioty	Phase 4	Completed	-	Egypt ... 展开 >> Kasr Alainy medical school Cairo, Egypt, 12151 收起 <<
NCT00446199	Vasomotor Symptoms ... 展开 >> Hot Flashes 收起 <<	Phase 3	Completed	-	-
NCT00335257	-		Completed	-	Germany ... 展开 >> Center for Epidemiology and Health Research Berlin, Germany, 10115 收起 <<
NCT00446199	-		Completed	-	-
NCT00335257	-		Completed	-	-
NCT01360996	Polycystic Ovary Syndrome	Phase 4	Completed	-	United States, Louisiana ... 展开 >> Woman's Hospital Baton Rouge, Louisiana, United States, 70815 收起 <<
NCT01360996	-		Completed	-	-
NCT02027337	Polycystic Ovarian Syndrome ... 展开 >> Hyperandrogenism Menstrual Irregularities 收起 <<	Phase 4	Unknown	October 2015	Russian Federation ... 展开 >> Tyumen State Medical Academy Recruiting Tyumen, Russian Federation, 3452 Contact: Tatyana N Khvoschina hvoschina-t@yandex.ru Principal Investigator: Tatyana N Khvoschina 收起 <<
NCT01257984	Contraception	Phase 3	Completed	-	-
NCT00656981	Acne Vulgaris	Phase 3	Completed	-	United States, Alabama ... 展开 >> Mobile, Alabama, United States, 36608 United States, Arizona Kingman, Arizona, United States, 86401 United States, California Encino, California, United States, 91436 San Diego, California, United States, 92103 San Diego, California, United States, 92123 Westlake Village, California, United States, 91361 United States, Colorado Castle Rock, Colorado, United States, 80108 Denver, Colorado, United States, 80246 United States, Florida Palm Springs, Florida, United States, 33461 St. Petersburg, Florida, United States, 33702 Venice, Florida, United States, 34285 United States, Idaho Boise, Idaho, United States, 83704 United States, Kansas Shawnee, Kansas, United States, 66203 United States, Kentucky Louisville, Kentucky, United States, 40217 United States, Minnesota Fridley, Minnesota, United States, 55432 United States, New York East Steauket, New York, United States, 11733 New York, New York, United States, 10022 United States, Oregon Medford, Oregon, United States, 97504 Portland, Oregon, United States, 97223-6683 United States, Texas Byran, Texas, United States, 77801 United States, Virginia Arlington, Virginia, United States, 22203 United States, Washington Seattle, Washington, United States, 98105 收起 <<
NCT00569244	Primary Dysmenorrhea	Phase 3	Completed	-	Germany ... 展开 >> Heidelberg, Baden-Württemberg, Germany, 69120 Nürnberg, Bayern, Germany, 90491 Frankfurt, Hessen, Germany, 60439 Fulda, Hessen, Germany, 36037 Mühlheim, Hessen, Germany, 63165 Hannover, Niedersachsen, Germany, 30159 Hannover, Niedersachsen, Germany, 30459 Bernburg, Sachsen-Anhalt, Germany, 06406 Blankenburg, Sachsen-Anhalt, Germany, 38889 Burg, Sachsen-Anhalt, Germany, 39288 Jessen, Sachsen-Anhalt, Germany, 06917 Magdeburg, Sachsen-Anhalt, Germany, 39104 Magdeburg, Sachsen-Anhalt, Germany, 39126 Magdeburg, Sachsen-Anhalt, Germany, 39130 Leipzig, Sachsen, Germany, 04207 Leipzig, Sachsen, Germany, 04277 Leipzig, Sachsen, Germany, 04299 Wurzen, Sachsen, Germany, 04808 Gera, Thüringen, Germany, 07545 Kahla, Thüringen, Germany, 07768 Berlin, Germany, 10247 Berlin, Germany, 10409 Berlin, Germany, 12587 Berlin, Germany, 13086 United Kingdom Chesterfield, Derbyshire, United Kingdom, S40 4TF Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE4 5BE London, United Kingdom, W12 0HS 收起 <<
NCT00651469	Acne Vulgaris	Phase 3	Completed	-	-
NCT03037944	Adenomyosis	Early Phase 1	Recruiting	December 1, 2018	Egypt ... 展开 >> Ain Shams University - Maternity Hospital Recruiting Cairo, Egypt Contact: Asmaa MA Mohamdy, Bachelors +201008340829 dr.asmaamamdoh@gmail.com Principal Investigator: Karim Ah Wahba, Asst.Prof Sub-Investigator: Karim Mo Labib, Lecturer Sub-Investigator: Mohamed Es Abbass, Lecturer 收起 <<
NCT00102141	Hypertension ... 展开 >>Postmenopause 收起 <<	Phase 3	Completed	-	-
NCT02617537	Dysmenorrhea	Phase 3	Withdrawn	October 2017	-
NCT01697111	Endometriosis	Phase 3	Completed	-	Japan ... 展开 >> Anjo, Aichi, Japan, 446-8510 Ichinomiya, Aichi, Japan, 491-8551 Nagoya, Aichi, Japan, 451-8511 Nagoya, Aichi, Japan, 460-0011 Nagoya, Aichi, Japan, 464-0066 Matsudo, Chiba, Japan, 270-2267 Takasaki, Gunma, Japan, 370-0883 Itami, Hyogo, Japan, 664-8540 Kawanishi, Hyogo, Japan, 666-0125 Kobe, Hyogo, Japan, 654-0047 Kanazawa, Ishikawa, Japan, 920-8530 Kamakura, Kanagawa, Japan, 247-8533 Kawasaki, Kanagawa, Japan, 212-0016 Yokohama, Kanagawa, Japan, 230-0001 Yokohama, Kanagawa, Japan, 231-0023 Toyonaka, Osaka, Japan, 560-0022 Kitamoto, Saitama, Japan, 364-8501 Bunkyo, Tokyo, Japan, 112-0014 Chuo-ku, Tokyo, Japan, 104-0061 Fuchu, Tokyo, Japan, 183-0056 Hachioji, Tokyo, Japan, 192-0046 Itabashi, Tokyo, Japan, 175-0092 Machida, Tokyo, Japan, 194-0022 Minato, Tokyo, Japan, 105-0001 Minato, Tokyo, Japan, 107-0051 Nishitokyo, Tokyo, Japan, 188-0011 Fukui, Japan, 910-0845 Fukui, Japan, 910-8526 Gifu, Japan, 500-8717 Osaka, Japan, 530-0001 Osaka, Japan, 530-0013 Osaka, Japan, 542-0086 收起 <<
NCT00185484	Contraception	Phase 3	Completed	-	-
NCT00266032	Contraception	Phase 3	Completed	-	Canada, Quebec ... 展开 >> Drummondville, Quebec, Canada, J2B 1H8 Montreal, Quebec, Canada, H1T 1P6 Pointe-Claire, Quebec, Canada, H9R 4S3 Shawinigan, Quebec, Canada, G9N 2H6 Ste-Foy, Quebec, Canada, G1V 4X7 Canada Quebec, Canada, G1S 2L6 Germany Ettlingen, Baden-Württemberg, Germany, 76275 Karlsruhe, Baden-Württemberg, Germany, 76199 Ansbach, Bayern, Germany, 91522 Krumbach, Bayern, Germany, 86381 Nürnberg, Bayern, Germany, 90491 Dietzenbach, Hessen, Germany, 63128 Frankfurt, Hessen, Germany, 60322 Frankfurt, Hessen, Germany, 60439 Frankfurt, Hessen, Germany, 65929 Frankfurt, Hessen, Germany, 65936 Mühlheim, Hessen, Germany, 63165 Bovenden, Niedersachsen, Germany, 37120 Hannover, Niedersachsen, Germany, 30459 Osnabrück, Niedersachsen, Germany, 49074 Bernburg, Sachsen-Anhalt, Germany, 06406 Jessen, Sachsen-Anhalt, Germany, 06917 Magdeburg, Sachsen-Anhalt, Germany, 39104 Magdeburg, Sachsen-Anhalt, Germany, 39126 Magdeburg, Sachsen-Anhalt, Germany, 39130 Wurzen, Sachsen, Germany, 04808 Gera, Thüringen, Germany, 07545 Jena, Thüringen, Germany, 07747 Kahla, Thüringen, Germany, 07768 Berlin, Germany, 10115 Berlin, Germany, 10247 Berlin, Germany, 12435 Berlin, Germany, 13187 Hamburg, Germany, 21073 Netherlands Groningen, Netherlands, 9713 GZ 收起 <<
NCT00819312	Contraception	Phase 3	Completed	-	China, Guangdong ... 展开 >> Guangzhou, Guangdong, China, 510120 Guangzhou, Guangdong, China China, Hubei Wuhan, Hubei, China, 430022 China, Jiangsu Nanjing, Jiangsu, China, 210006 Nanjing, Jiangsu, China, 210009 Yangzhou, Jiangsu, China, 225001 China, Liaoning Shenyang, Liaoning, China, 110004 China, Shandong Jinan, Shandong, China China, Shanxi Xi An, Shanxi, China, 710032 China, Sichuan Chengdu, Sichuan, China China Beijing, China, 100034 Beijing, China, 100044 Chongqing, China, 400010 Chongqing, China Shanghai, China, 200011 Shanghai, China, 200127 Hong Kong Hongkong, Hong Kong 收起 <<
NCT00522873	Postmenopause	Phase 3	Completed	-	-
NCT00522873	-		Completed	-	-
NCT00266032	-		Completed	-	-
NCT01254292	Contraception	Phase 3	Completed	-	-
NCT00511199	Contraception	Phase 3	Completed	-	-
NCT01254292	-		Completed	-	-
NCT01432028	Postmenopause	Not Applicable	Completed	-	Brazil ... 展开 >> Hospital de Clínicas de Porto Alegre Porto Alegre, Rio Grande do Sul, Brazil 收起 <<
NCT00511199	-		Completed	-	-
NCT00413062	Contraception	Phase 3	Completed	-	-
NCT01603745	Polycystic Ovary Syndrome	Phase 1	Unknown	October 2012	Italy ... 展开 >> Catholic university of Sacred Heart Recruiting Rome, Italy, 00168 Contact: Rosanna Apa, MD sandrina84@hotmail.com Principal Investigator: Rosanna Apa, MD 收起 <<
NCT00511433	-		Completed	-	-
NCT00511433	Contraception	Phase 3	Completed	-	-
NCT01195974	Infection, Human Immunodeficie... 展开 >>ncy Virus 收起 <<	Phase 1	Terminated(In a Phase II study... 展开 >> in HIV-infected patients there were a number of seizures, although exact causality could not be assessed phase 1 activity was terminated.) 收起 <<	-	United States, North Dakota ... 展开 >> GSK Investigational Site Fargo, North Dakota, United States, 58104 收起 <<
NCT00988910	-		Completed	-	Italy ... 展开 >> Many Locations, Italy 收起 <<
NCT00633360	Premenstrual Syndrome ... 展开 >> Depression 收起 <<	Not Applicable	Completed	-	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 收起 <<
NCT00633360	-		Completed	-	-
NCT00413062	-		Completed	-	-
NCT00640224	-		Completed	-	-
NCT00631124	Contraception	Phase 2	Completed	-	Germany ... 展开 >> Berlin, Germany, 10115 Berlin, Germany, 13353 收起 <<
NCT00653614	Contraceptive, Oral, Hormonal	Phase 2	Completed	-	Germany ... 展开 >> Krumbach, Bayern, Germany, 86381 Nürnberg, Bayern, Germany, 90491 Dietzenbach, Hessen, Germany, 63128 Frankfurt, Hessen, Germany, 60322 Frankfurt, Hessen, Germany, 65936 Fulda, Hessen, Germany, 36037 Mühlheim, Hessen, Germany, 63165 Blankenburg, Sachsen-Anhalt, Germany, 38889 Burg, Sachsen-Anhalt, Germany, 39288 Jessen, Sachsen-Anhalt, Germany, 06917 Magdeburg, Sachsen-Anhalt, Germany, 39104 Magdeburg, Sachsen-Anhalt, Germany, 39126 Dippoldiswalde, Sachsen, Germany, 01744 Dresden, Sachsen, Germany, 01099 Dresden, Sachsen, Germany, 01169 Leipzig, Sachsen, Germany, 04207 Leipzig, Sachsen, Germany, 04299 Wurzen, Sachsen, Germany, 04808 Gera, Thüringen, Germany, 07545 Berlin, Germany, 10247 Berlin, Germany, 12587 Berlin, Germany, 13086 Berlin, Germany, 13507 Hamburg, Germany, 21073 Hamburg, Germany, 22159 收起 <<
NCT02874248	Contraception	Phase 1	Completed	-	-
NCT00640224	Polycystic Ovary Syndrome	Phase 4	Completed	-	United States, Pennsylvania ... 展开 >> Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15224 收起 <<
NCT00420342	Postmenopause ... 展开 >> Hypertension Pre-Hypertension 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Greenbrae, California, United States, 94904 San Diego, California, United States, 92108 United States, Florida Daytona Beach, Florida, United States, 32114 Miami, Florida, United States, 33136 United States, Michigan Paw Paw, Michigan, United States, 49079 United States, Nevada Las Vegas, Nevada, United States, 89122 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19114 United States, South Carolina Columbia, South Carolina, United States, 29201 United States, Virginia Arlington, Virginia, United States, 22203 收起 <<
NCT00420342	-		Completed	-	-
NCT00302848	-		Completed	-	Germany ... 展开 >> Center for Epidemiology and Health Research Berlin, Germany, 10115 收起 <<
NCT03074045	Contraception	Phase 3	Active, not recruiting	September 1, 2022	Russian Federation ... 展开 >> Altai State Medical University Barnaul, Russian Federation, 656038 Scientific Center of family health & human reprod. problems Irkutsk, Russian Federation, 664003 Krasnoyarsk State Medical University Krasnoyarsk, Russian Federation, 660022 City Clinical Hospital #13 Moscow, Russian Federation, 115280 LLC Reafan Novosibirsk, Russian Federation, 630099 Medical Center "Avicenna" Novosibirsk, Russian Federation, 630099 Smolensk State Medical University Smolensk, Russian Federation, 214019 LLC Medical center PRIME ROSE St. Petersburg, Russian Federation, 197374 Regional perinatal center Yaroslavl, Russian Federation, 150042 收起 <<
NCT00302848	-		Completed	-	-
NCT00468481	Neural Tube Defects ... 展开 >> Contraception Oral Contraceptives (OC) 收起 <<	Phase 3	Completed	-	United States, California ... 展开 >> Orange County Clinical Trials Anaheim, California, United States, 92801 Medical Center for Clinical Research San Diego, California, United States, 92108 United States, Maryland SNBL Clinical Pharmacology Center, Inc. Baltimore, Maryland, United States, 21201 United States, New York Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina AAIPharma, Inc. Morrisville, North Carolina, United States, 27560 Lyndhurst Gynecologic Associates Winston-Salem, North Carolina, United States, 27103 United States, South Carolina Coastal Carolina Research Center Mt. Pleasant, South Carolina, United States, 29464 United States, Tennessee New Orleans Center for Clinical Research Knoxville, Tennessee, United States, 37920 United States, Washington NorthWest Kinetics Tacoma, Washington, United States, 98418 收起 <<
NCT03091595	Prevention of Pregnancy	Phase 2	Completed	-	Netherlands ... 展开 >> Dinox BV Groningen, Netherlands, 9713 CZ 收起 <<
NCT01258660	Contraception	Phase 1	Completed	-	Germany ... 展开 >> Nuvisan GmbH Neu-Ulm, Bayern, Germany, 89231 收起 <<
NCT00468481	-		Completed	-	-
NCT01892904	Dysmenorrhea	Phase 3	Completed	-	Japan ... 展开 >> Matsudo, Chiba, Japan, 270-2267 Hachioji, Tokyo, Japan, 192-0046 Minato, Tokyo, Japan, 108-0071 Setagaya-ku, Tokyo, Japan, 157-0066 Suginami-ku, Tokyo, Japan, 167-0051 Toshima-ku, Tokyo, Japan, 171-0021 Osaka, Japan, 530-0013 Osaka, Japan, 542-0086 收起 <<
NCT01258660	-		Completed	-	-
NCT00367276	Healthy	Phase 3	Completed	-	-
NCT01902264	Contraception	Phase 3	Completed	-	Mexico ... 展开 >> Mexico, D.F., Distrito Federal, Mexico, CP 14050 收起 <<
NCT02957630	Contraception ... 展开 >> Liver Metabolism Hemostasis Parameter 收起 <<	Phase 1 Phase 2	Completed	-	Netherlands ... 展开 >> Dinox BV Groningen, Netherlands, 9713 GZ 收起 <<
NCT02757469	Primary Ovarian Insufficiency ... 展开 >> Menopause, Premature 收起 <<	Not Applicable	Not yet recruiting	May 2021	China, Beijing ... 展开 >> Navy General Hospital Not yet recruiting Beijing, Beijing, China, 100048 Contact: Yunhai Chuai, Dr +86-18810892004 wangyh85@foxmail.com Principal Investigator: Wei Shang, Dr Principal Investigator: Lei Chen, Dr Principal Investigator: Yunhai Chuai, Dr Sub-Investigator: Mingming Shu, Dr Sub-Investigator: Ming Zhou, Dr Sub-Investigator: Mengnan Chen, Dr Sub-Investigator: Huiming Han, Dr 收起 <<
NCT03512860	Contraception	Phase 1	Completed	-	United Kingdom ... 展开 >> Quotient Sciences Ruddington, Nottingham, United Kingdom, NG11 6JS 收起 <<
NCT03124524	Primary Dysmenorrhea	Phase 4	Completed	-	-
NCT02384408	Menopause	Phase 4	Completed	-	Brazil ... 展开 >> Vale Do Sapucai University (Univas) Pouso Alegre, MG, Brazil, 37550-000 收起 <<
NCT00915174	Healthy	Phase 1	Completed	-	Germany ... 展开 >> AAIharma Deutschland GmbH & Co. KG Neu Ulm, Bavaria, Germany, 89231 收起 <<
NCT00722761	Acne Vulgaris	Phase 3	Completed	-	United States, Massachusetts ... 展开 >> Clinical Unit for Research Trials in Skin Boston, Massachusetts, United States, 02114 收起 <<
NCT00722800	-		Terminated(Poor recruitment)	-	-
NCT01581814	Polycystic Ovary Syndrome	Phase 3	Completed	-	Italy ... 展开 >> Policlinico A. Gemelli Rome, Italy, 00168 收起 <<
NCT00722761	-		Completed	-	-
NCT01511822	PCOS Polycyst... 展开 >>ic Ovary Syndrome 收起 <<	Phase 4	Completed	-	Italy ... 展开 >> Istituto di Patologia Ostetrica e Ginecologica Catania, Italy 收起 <<
NCT01253174	Contraception	Phase 1	Completed	-	Germany ... 展开 >> Scope International Hamburg, Germany, 22525 收起 <<
NCT00461305	Dysmenorrhea	Phase 2 Phase 3	Completed	-	Japan ... 展开 >> Nagoya, Aichi, Japan, 460-0007 Nagoya, Aichi, Japan, 460-0011 Nagoya, Aichi, Japan, 464-0066 Maebashi, Gunma, Japan, 371-0024 Takasaki, Gunma, Japan, 370-0883 Kobe, Hyogo, Japan, 650-0021 Nishinomiya, Hyogo, Japan, 663-8204 Yamato, Kanagawa, Japan, 242-0007 Yokohama, Kanagawa, Japan, 231-0861 Sendai, Miyagi, Japan, 980-0021 Sendai, Miyagi, Japan, 981-0933 Sendai, Miyagi, Japan, 984-0042 Toyonaka, Osaka, Japan, 560-0022 Chuo-ku, Tokyo, Japan, 104-0061 Hachioji, Tokyo, Japan, 192-0046 Machida, Tokyo, Japan, 194-0022 Musashino, Tokyo, Japan, 180-0003 Ota-ku, Tokyo, Japan, 144-0052 Setagaya-ku, Tokyo, Japan, 156-0042 Setagaya-ku, Tokyo, Japan, 157-0066 Shibuya-ku, Tokyo, Japan, 150-0013 Shinagawa-ku, Tokyo, Japan, 140-0013 Suginami-ku, Tokyo, Japan, 167-0051 Toshima-ku, Tokyo, Japan, 171-0021 Osaka, Japan, 530-0013 Osaka, Japan, 534-0014 收起 <<
NCT00356447	Vasomotor Symptoms	Phase 3	Completed	-	China, Hubei ... 展开 >> Wuhan, Hubei, China, 430032 China, Jiangsu Nanjing, Jiangsu, China, 210029 China, Shandong Jinan, Shandong, China, 250012 China Beijing, China, 100020 Beijing, China, 100034 Beijing, China, 100083 Beijing, China, 100730 Chongqing, China, 400010 Shanghai, China, 200011 收起 <<
NCT00722800	Hidradenitis Suppurativa	Phase 2	Terminated(Poor recruitment)	-	United States, Massachusetts ... 展开 >> Clinical Unit for Research Trials in Skin Boston, Massachusetts, United States, 02114 收起 <<
NCT01253187	-		Completed	-	-
NCT00461305	-		Completed	-	-
NCT01253174	-		Completed	-	-
NCT01253187	Contraception	Phase 1	Completed	-	Netherlands ... 展开 >> Dinox B.V. Groningen, Netherlands, 9713GZ 收起 <<
NCT00511797	Dysmenorrhea	Phase 2 Phase 3	Completed	-	Japan ... 展开 >> Maebashi, Gunma, Japan, 371-0024 Kobe, Hyogo, Japan, 650-0021 Nishinomiya, Hyogo, Japan, 663-8204 Yokohama, Kanagawa, Japan, 231-0861 Sendai, Miyagi, Japan, 981-0933 Chuo-ku, Tokyo, Japan, 104-0061 Hachioji, Tokyo, Japan, 192-0046 Setagaya-ku, Tokyo, Japan, 156-0042 Setagaya-ku, Tokyo, Japan, 157-0066 Toshima-ku, Tokyo, Japan, 171-0021 Kyoto, Japan, 612-0064 Osaka, Japan, 530-0013 收起 <<
NCT00511797	-		Completed	-	-
NCT00745901	Contraception	Phase 4	Completed	-	-
NCT00818519	-		Completed	-	-
NCT01608698	Body Weight Changes	Phase 4	Unknown	February 2016	Thailand ... 展开 >> Family Planning Unit, Department of Obstetric and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 收起 <<
NCT02852681	Contraception	Phase 1	Completed	-	-
NCT00818519	Acne Vulgaris	Phase 3	Completed	-	China, Guangdong ... 展开 >> Guangzhou, Guangdong, China, 510630 China, Hunan Changsha, Hunan, China, 410011 China, Jiangsu Nanjing, Jiangsu, China, 210042 China, Sichuan Chengdu, Sichuan, China, 610041 China Beijing, China, 100032 Beijing, China, 100853 Shanghai, China, 200043 收起 <<
NCT01109979	-		Completed	-	-
NCT00745901	-		Completed	-	-
NCT02269241	Contraception	Phase 3	Completed	-	-
NCT01590849	Contraceptive Affecting the Au... 展开 >>tonomic Nervous System Contraceptive Affecting Blood Pressure 收起 <<	Phase 3	Unknown	-	Brazil ... 展开 >> Marcelo Gil Nisenbaum Sao Paulo, São Paulo, Brazil, 05403-000 收起 <<
NCT02342093	Blood Pressure ... 展开 >> Contraception 收起 <<	Phase 4	Completed	-	Brazil ... 展开 >> University of Sao Paulo Ribeirão Preto, SP, Brazil, 14049-900 收起 <<
NCT01109979	Cardiovascular Diseases	Phase 4	Completed	-	United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 收起 <<
NCT01519401	Polycystic Ovary Syndrome ... 展开 >> Estro-progestin Drugs 收起 <<	Not Applicable	Completed	-	Italy ... 展开 >> Catholic University of Sacred Heart Rome, Italy, 00168 收起 <<
NCT01182207	Healthy	Phase 1	Completed	-	United States, North Dakota ... 展开 >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 收起 <<
NCT01482338	Premenstrual Syndrome	Phase 4	Completed	-	Thailand ... 展开 >> Family Unit, King Chulalongkorn Memorial Hospital Bangkok, Thailand, 10330 收起 <<
NCT02885454	Healthy	Phase 1	Completed	-	United States, Kansas ... 展开 >> Overland Park, Kansas, United States 收起 <<
NCT01182194	Healthy	Phase 1	Completed	-	United States, North Dakota ... 展开 >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 收起 <<
NCT01182207	-		Completed	-	-
NCT01459445	Polycystic Ovary Syndrome ... 展开 >> Endothelial Dysfunction 收起 <<	Not Applicable	Unknown	January 2012	Romania ... 展开 >> Clinic of Endocrinology Cluj-Napoca, Cluj, Romania, 400349 收起 <<
NCT03126097	Healthy	Phase 1	Terminated(Study stopping rule... 展开 >>s were met.) 收起 <<	-	United States, Arizona ... 展开 >> Celerion Tempe, Arizona, United States, 85283 收起 <<
NCT03111511	Healthy	Phase 1	Completed	-	Belgium ... 展开 >> Clinical Pharmacology Unit Merksem, Belgium, 2170 收起 <<
NCT02817828	Contraception	Phase 3	Completed	-	Belgium ... 展开 >> Hopital Saint-Pierre Bruxelles, Belgium, 1000 收起 <<
NCT02817841	Contraception	Phase 3	Completed	-	United States, Pennsylvania ... 展开 >> Thomas Jefferson University Obstetrics and Gynecology Philadelphia, Pennsylvania, United States, 19107 Canada Clinique de Santé des Femmes Quebec, Canada, G1S 2L6 收起 <<
NCT01182194	-		Completed	-	-

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