Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles and also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 0.81 μM.
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Direct Blue 1, known as Chicago Sky Blue 6B, is employed to quench background autofluorescence in immunofluorescence histochemistry. It acts as a potent and competitive inhibitor of VGLUT and can block the binding of Aβ to small molecule PrP ligands. Direct Blue 1 exhibits anti-inflammatory properties[1][2][3][4][5][6].
体内研究
Administering Direct Blue 1 at doses of 2 or 8 mg/kg subcutaneously for four weeks mitigates inflammatory bone destruction and osteoporosis prompted by titanium particles in mice[5].
Intraventricular injection of 7.5 μg of Direct Blue 1 alleviates the hyperactivity and behavioral sensitization induced by methamphetamine in mice[6].
体外研究
Direct Blue 1, at concentrations of 0.1, 1, and 10 μM over nine days, can associate with α-synuclein to inhibit its aggregation, thereby hindering the proliferation of α-synuclein among SH-SY5Y cells[4].
Direct Blue 1, at 5, 10, and 20 μM for 48 hours, suppresses RANKL-induced osteoclastogenesis and bone resorption in vitro by inhibiting the NF-κB signaling pathway and promoting proteasome-mediated MIF degradation[5].
Tags:
Direct Blue 1 | 2610-05-1 | Chicago Sky Blue 6B | Direct Blue1 | Direct Blue-1 | VGLUT Inhibitor | Neuronal Signaling | NF-κB | Amyloid-β | NF-κB | 仅供科研使用 | AmBeed-信号通路专用抑制剂
| Direct Blue 1 纯度/质量文件
| Direct Blue 1 生物活性
| Direct Blue 1 参考文献
| Direct Blue 1 实验方案
| Direct Blue 1 技术信息
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