Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles and also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 0.81 μM.
Direct Blue 1, known as Chicago Sky Blue 6B, is employed to quench background autofluorescence in immunofluorescence histochemistry. It acts as a potent and competitive inhibitor of VGLUT and can block the binding of Aβ to small molecule PrP ligands. Direct Blue 1 exhibits anti-inflammatory properties[1][2][3][4][5][6].
体内研究
Administering Direct Blue 1 at doses of 2 or 8 mg/kg subcutaneously for four weeks mitigates inflammatory bone destruction and osteoporosis prompted by titanium particles in mice[5].
Intraventricular injection of 7.5 μg of Direct Blue 1 alleviates the hyperactivity and behavioral sensitization induced by methamphetamine in mice[6].
体外研究
Direct Blue 1, at concentrations of 0.1, 1, and 10 μM over nine days, can associate with α-synuclein to inhibit its aggregation, thereby hindering the proliferation of α-synuclein among SH-SY5Y cells[4].
Direct Blue 1, at 5, 10, and 20 μM for 48 hours, suppresses RANKL-induced osteoclastogenesis and bone resorption in vitro by inhibiting the NF-κB signaling pathway and promoting proteasome-mediated MIF degradation[5].
Tags:
Direct Blue 1 | 2610-05-1 | Chicago Sky Blue 6B | Direct Blue1 | Direct Blue-1 | VGLUT Inhibitor | Neuronal Signaling | NF-κB | Amyloid-β | NF-κB | 仅供科研使用 | AmBeed-信号通路专用抑制剂
| Direct Blue 1 纯度/质量文件
| Direct Blue 1 生物活性
| Direct Blue 1 参考文献
| Direct Blue 1 实验方案
| Direct Blue 1 技术信息
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