Difluprednate | W-6309 | Anti-inflammatory Agent | AmBeed-信号通路专用抑制剂

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二氟孕甾丁酯 /Difluprednate {[allProObj[0].p_purity_real_show]}

货号：A794471 同义名： W-6309

Difluprednate is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Difluprednate 化学结构
CAS号：23674-86-4

Difluprednate 3D分子结构
CAS号：23674-86-4

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Difluprednate 纯度/质量文件产品仅供科研

货号：A794471 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Difluprednate 生物活性

描述

Difluprednate is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain. Topical difluprednate is potentially effective and safe in preventing graft rejection after penetrating keratoplasty^[3]. Difluprednate is effective for managing ocular manifestations of Harada's disease^[4]. Difluprednate is also an effective treatment for patients with severe pseudophakic cystoid macular edema^[5]. Difluprednate 0.05% four times daily showed safety and efficacy profiles similar to prednisolone acetate 1% four times daily in children 0-3 years undergoing cataract surgery^[6]. Two months after initiation of topical difluprednate, fluorescein angiography demonstrated resolution of retinal vasculitis in both treated eyes^[7].

Difluprednate 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03626376	Herpes Simplex Virus Keratitis	Phase 4	Not yet recruiting	October 2019	United States, New York ... 展开 >> New York University School of Medicine Not yet recruiting New York, New York, United States, 10016 Contact: Stacy Mach 929-455-5539 Stacy.Mach@nyumc.org Principal Investigator: Leela Raju, MD 收起 <<
NCT01541527	-		Withdrawn(Promoter's change)	-	France ... 展开 >> CHU de Montpellier- Centre administratif André Benech Montpellier, France, 3400 收起 <<
NCT02215863	Influenza Str... 展开 >>eptococcus Pneumoniae 收起 <<	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Korea University Ansan Hospital Ansan, Korea, Republic of Hallym University Gangnam Sacred Hospita Seoul, Korea, Republic of Catholic University Medical College, St. Vincent's Hospital Suwon, Korea, Republic of 收起 <<

Difluprednate 参考文献

[1]Donnenfeld ED. Difluprednate for the prevention of ocular inflammation postsurgery: an update. Clin Ophthalmol. 2011;5:811-6.

[2]Jamal KN, Callanan DG. The role of difluprednate ophthalmic emulsion in clinical practice. Clin Ophthalmol. 2009;3:381-90.

[3]Said OM, Saleh MGA, Omar AF, Abdou AA, Riad Mostafa AN. Topical Difluprednate for Early Corneal Graft Rejection After Penetrating Keratoplasty. Clin Ophthalmol. 2020 Oct 27;14:3495-3498

[4]Onishi SM, Asahi MG, Chou C, Gallemore RP. Topical difluprednate for the treatment of Harada's disease. Clin Ophthalmol. 2015 Jan 21;9:157-67

[5]Chalam K, Khetpal V, Patel CJ. Spectral domain optical coherence tomography documented rapid resolution of pseudophakic cystoid macular edema with topical difluprednate. Clin Ophthalmol. 2012;6:155-8

[6]Wilson ME, O'Halloran H, VanderVeen D, Roarty J, Plager DA, Markwardt K, Gedif K, Lambert SR. Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients: a randomized safety and efficacy study. Eye (Lond). 2016 Sep;30(9):1187-94

[7]Wang JC, Burkholder BM, Butler NJ. Topical difluprednate for the treatment of retinal vasculitis associated with birdshot chorioretinitis. Am J Ophthalmol Case Rep. 2016 Apr 29;3:22-24

Difluprednate 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.83mL

1.97mL

0.98mL

19.66mL

3.93mL

1.97mL

Difluprednate 技术信息

CAS号	23674-86-4
分子式	C₂₇H₃₄F₂O₇
分子量	508.551

别名	W-6309
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 250 mg/mL(491.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03626376	Herpes Simplex Virus Keratitis	Phase 4	Not yet recruiting	October 2019	United States, New York ... 展开 >> New York University School of Medicine Not yet recruiting New York, New York, United States, 10016 Contact: Stacy Mach 929-455-5539 Stacy.Mach@nyumc.org Principal Investigator: Leela Raju, MD 收起 <<
NCT01541527	-		Withdrawn(Promoter's change)	-	France ... 展开 >> CHU de Montpellier- Centre administratif André Benech Montpellier, France, 3400 收起 <<
NCT02215863	Influenza Str... 展开 >>eptococcus Pneumoniae 收起 <<	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Korea University Ansan Hospital Ansan, Korea, Republic of Hallym University Gangnam Sacred Hospita Seoul, Korea, Republic of Catholic University Medical College, St. Vincent's Hospital Suwon, Korea, Republic of 收起 <<
NCT00501579	Uveitis	Phase 3	Completed	-	United States, Indiana ... 展开 >> John-Kenyon American Eye Institute New Albany, Indiana, United States, 47150 收起 <<
NCT03693989	Cataract	Phase 3	Not yet recruiting	September 30, 2019	-
NCT00407056	Uveitis Panuv... 展开 >>eitis 收起 <<	Phase 3	Completed	-	-
NCT01276223	Dry Eye Disease	Phase 2	Completed	-	United States, Texas ... 展开 >> Contact Alcon Call Center at 1-888-451-3937 for Trial Locations Fort Worth, Texas, United States, 76134 收起 <<
NCT00406497	Inflammation	Phase 2	Completed	-	-
NCT00405496	Anterior Uveitis	Phase 2	Completed	-	-
NCT00406341	Inflammation	Phase 3	Completed	-	-
NCT00407225	Inflammation	Phase 2	Completed	-	-
NCT01276223	-		Completed	-	-
NCT00406887	Anterior Uveitis ... 展开 >> Panuveitis 收起 <<	Phase 3	Completed	-	-
NCT00616993	Inflammation	Phase 3	Completed	-	United States, Florida ... 展开 >> Eye Associates of Fort Myers Fort Myers, Florida, United States, 33901 收起 <<
NCT00616070	Inflammation	Phase 3	Completed	-	United States, North Carolina ... 展开 >> Charlotte Eye, Ear, Nose & Throat Charlotte, North Carolina, United States, 28210 收起 <<
NCT01124045	Cataracts Inf... 展开 >>lammation 收起 <<	Phase 3	Completed	-	United States, Texas ... 展开 >> Contact Alcon Call Center For Trial Locations Fort Worth, Texas, United States, 76134 收起 <<
NCT00429923	Inflammation	Phase 3	Completed	-	United States, Missouri ... 展开 >> Comprehensive Eye Care Washington, Missouri, United States, 63090 收起 <<
NCT01201798	-		Completed	-	-
NCT01244334	Cataracts Cor... 展开 >>neal Edema Retinal Structural Change, Deposit and Degeneration Visual Acuity Reduced Transiently 收起 <<	Phase 4	Completed	-	United States, Kentucky ... 展开 >> Cincinnati Eye Institute Edgewood, Kentucky, United States, 41017 United States, New York Ophthalmic Consultants of Long Island Lynbrook, New York, United States, 11563 United States, South Carolina Carolina Eyecare Mt Pleasant, South Carolina, United States, 29464 收起 <<
NCT00430092	Inflammation	Phase 3	Completed	-	United States, Missouri ... 展开 >> Comprehensive Eye Care Washington, Missouri, United States, 63090 收起 <<
NCT00430092	-		Completed	-	-
NCT01939691	Uveitis Macul... 展开 >>ar Edema 收起 <<	Phase 4	Recruiting	January 2021	India ... 展开 >> Aravind Eye Hospital Recruiting Madurai, Tamil Nadu, India Contact: S.R. Rathinam Principal Investigator: S.R. Rathinam, FAMS, PhD Sub-Investigator: G. Vedhanayaki, DO 收起 <<
NCT01201798	Endogenous Anterior Uveitis	Phase 3	Completed	-	United States, Texas ... 展开 >> Contact Alcon Call Center Fort Worth, Texas, United States, 76134 收起 <<
NCT01124045	-		Completed	-	-
NCT00429923	-		Completed	-	-

二氟孕甾丁酯 /Difluprednate {[allProObj[0].p_purity_real_show]}

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最近浏览的产品

大规格询价

摩尔计算器

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