DiethylcarbamazineCitrate是一种抑制花环虫(丝虫)微丝蚴的花生四烯酸代谢的抑制剂,对几种寄生虫具有高度特异性,且不含任何有毒金属元素
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements[2]. Diethylcarbamazine citrate (DEC) is also anti-inflammatory drug. The only effective anti-inflammatory dose was 50mg/kg to reduce the high levels of glucose, insulin and triglycerides in serum. DEC was not anti-obesity drug because the weights of body, liver and adipose tissues were not changed. In addition, the activity of COX (cyclooxygenase) in DEC treatment decreased significantly, while NF-κBp65 localization in nuclear extracts was obviously inhibited in 50mg/kg treated group[3]. Within 10 s of an intravenous injection of DECC(diethylcarbamazine citrate) (2.5 to 10 mg/kg) there was hypotension, bradycardia and there were reductions in left ventricular and carotid artery dP/dt max. DECC (5 or 10 mg/kg) significantly inhibited prostaglandin F2alpha-induced increases in peak inspiratory intra-tracheal pressure without modifying its pulmonary hypertensive effect[4]. The effect of S. equina ES (excretory-secretory) as antioxidant against rat HCC (hepatocellular carcinoma ), while DEC could modulate such effect when combined with it[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01905423 | - | Completed | - | Indonesia ... 展开 >> University of Indonesia, Department of Parasitology Jakarta, Java, Indonesia, 10430 收起 << | |
NCT01905423 | - | Completed | - | - | |
NCT03676140 | Trachoma Yaws... 展开 >> Lymphatic Filariases Scabies Strongyloidiasis 收起 << | Phase 3 | Not yet recruiting | January 2019 | - |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.55mL 0.51mL 0.26mL |
12.77mL 2.55mL 1.28mL |
25.55mL 5.11mL 2.55mL |
CAS号 | 1642-54-2 |
分子式 | C16H29N3O8 |
分子量 | 391.417 |
别名 | 枸橼酸乙胺嗪 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere,Room Temperature |
溶解度 |
DMSO: 40 mg/mL(102.19 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(255.48 mM),配合低频超声助溶 |
动物实验配方 |