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枸橼酸二乙碳酰嗪 /DiethylcarbamazineCitrate {[allProObj[0].p_purity_real_show]}

货号:A553770 同义名: 枸橼酸乙胺嗪

DiethylcarbamazineCitrate是一种抑制花环虫(丝虫)微丝蚴的花生四烯酸代谢的抑制剂,对几种寄生虫具有高度特异性,且不含任何有毒金属元素

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
DiethylcarbamazineCitrate 化学结构 CAS号:1642-54-2
DiethylcarbamazineCitrate 化学结构
CAS号:1642-54-2
DiethylcarbamazineCitrate 3D分子结构
CAS号:1642-54-2
DiethylcarbamazineCitrate 化学结构 CAS号:1642-54-2
DiethylcarbamazineCitrate 3D分子结构 CAS号:1642-54-2
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DiethylcarbamazineCitrate 纯度/质量文件 产品仅供科研

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DiethylcarbamazineCitrate 生物活性

描述 Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements[2]. Diethylcarbamazine citrate (DEC) is also anti-inflammatory drug. The only effective anti-inflammatory dose was 50mg/kg to reduce the high levels of glucose, insulin and triglycerides in serum. DEC was not anti-obesity drug because the weights of body, liver and adipose tissues were not changed. In addition, the activity of COX (cyclooxygenase) in DEC treatment decreased significantly, while NF-κBp65 localization in nuclear extracts was obviously inhibited in 50mg/kg treated group[3]. Within 10 s of an intravenous injection of DECC(diethylcarbamazine citrate) (2.5 to 10 mg/kg) there was hypotension, bradycardia and there were reductions in left ventricular and carotid artery dP/dt max. DECC (5 or 10 mg/kg) significantly inhibited prostaglandin F2alpha-induced increases in peak inspiratory intra-tracheal pressure without modifying its pulmonary hypertensive effect[4]. The effect of S. equina ES (excretory-secretory) as antioxidant against rat HCC (hepatocellular carcinoma ), while DEC could modulate such effect when combined with it[5].

DiethylcarbamazineCitrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01905423 - Completed - Indonesia ... 展开 >> University of Indonesia, Department of Parasitology Jakarta, Java, Indonesia, 10430 收起 <<
NCT01905423 - Completed - -
NCT03676140 Trachoma Yaws... 展开 >> Lymphatic Filariases Scabies Strongyloidiasis 收起 << Phase 3 Not yet recruiting January 2019 -

DiethylcarbamazineCitrate 参考文献

[1]El-Shahawi GA, Abdel-Latif M, et al. Setaria equina: in vivo effect of diethylcarbamazine citrate on microfilariae in albino rats. Exp Parasitol. 2010 Dec;126(4):603-10.

[2]El-Shahawi GA, Abdel-Latif M, Saad AH, Bahgat M. Setaria equina: in vivo effect of diethylcarbamazine citrate on microfilariae in albino rats. Exp Parasitol. 2010;126(4):603‐610

[3]Abdel-Latif M. Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Int Immunopharmacol. 2015;29(2):607‐612

[4]Abaitey AK, Parratt JR. Cardiovascular effects of diethylcarbamazine citrate. Br J Pharmacol. 1976;56(2):219‐227. doi:10.1111/j.1476-5381.1976.tb07445.x

[5]Abdel-Latif M, Sakran T, El-Shahawi G, El-Fayoumi H, El-Mallah AM. Effect of diethylcarbamazine citrate and Setaria equina excretory-secretory material on rat hepatocellular carcinoma. Arch Immunol Ther Exp (Warsz). 2014;62(6):511‐520

DiethylcarbamazineCitrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.26mL

12.77mL

2.55mL

1.28mL

25.55mL

5.11mL

2.55mL

DiethylcarbamazineCitrate 技术信息

CAS号1642-54-2
分子式C16H29N3O8
分子量 391.417
别名 枸橼酸乙胺嗪
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature

溶解度

DMSO: 40 mg/mL(102.19 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(255.48 mM),配合低频超声助溶

动物实验配方
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