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4-氨基苯砜 /Dapsone {[allProObj[0].p_purity_real_show]}

货号：A240646 同义名： 氨苯砜;4,4'-二氨基二苯砜 / 4,4′-Diaminodiphenyl sulfone;DDS

Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties.

Dapsone 化学结构 CAS号：80-08-0
Dapsone 化学结构
CAS号：80-08-0
Dapsone 3D分子结构
CAS号：80-08-0
Dapsone 化学结构 CAS号：80-08-0
Dapsone 3D分子结构 CAS号：80-08-0
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Dapsone 纯度/质量文件 产品仅供科研

货号：A240646 标准纯度： {[allProObj[0].p_purity_real_show]}
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Dapsone 生物活性

描述 Dapsone, an antibiotic drug which is the principal in a multidrug regimen for the treatment of leprosy, is a sulfone with anti-inflammatory and antioxidant immunosuppressive properties[3]. Dapsone is a potent anti-inflammatory and anti-parasitic compound, which is metabolised by cytochrome P-450 to hydroxylamines, which in turn cause methaemoglobinaemia and haemolysis[4]. Dapsone is useful in the treatment of a number of inflammatory conditions which are characterized by neutrophil infiltration. It is the drug of choice for suppression of the symptoms of dermatitis herpetiformis, as it inhibits the process by which neutrophils leave the circulation and migrate to lesional sites[5]. Dapsone antagonized all of the I/R (ischemia-reperfusion) end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, anti-inflammatory, and anti-apoptotic effects[1]. Dapsone exerts cardioprotective effects on doxorubicin-induced cardiotoxicity through its anti-inflammatory and antioxidant mechanism[3].

Dapsone 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00141037 Kidney Diseases ... 展开 >> Kidney Transplantation Kidney Transplant Renal Transplantation Renal Transplant 收起 << Phase 1 Phase 2 Completed - United States, Alabama ... 展开 >> University of Alabama - Pediatric Nephrology Birmingham, Alabama, United States, 35233 United States, California Maxine Dunitz Children's Health Center Cedars-Sinai Los Angeles, California, United States, 90048 UCLA - Department of Pediatrics, Division of Nephrology Los Angeles, California, United States, 90095-1752 Stanford University Medical Center, Lucile Packard Children's Hospital Palo Alto, California, United States, 94304 UCSF Children's Hospital San Francisco, California, United States, 94143 United States, Florida University of Florida - Pediatric Nephrology Gainesville, Florida, United States, 32610-0296 United States, Louisiana Children's Hospital of New Orleans-Department of Pediatric Nephrology New Orleans, Louisiana, United States, 70118 United States, Massachusetts Children's Hospital Boston - Division of Nephrology Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Medical Center, C.S. Mott Children's Hospital- Division of Nephrology & Transplantation Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospital - Department of Nephrology Kansas City, Missouri, United States, 64108 United States, Pennsylvania The Children's Hospital of Philadelphia-Department of Nephrology Philadelphia, Pennsylvania, United States, 19104 United States, Washington Children's Hospital & Regional Medical Center - Division of Nephrology Seattle, Washington, United States, 98105 收起 <<
NCT00141037 - Completed - -
NCT02366884 Neoplasms Phase 2 Enrolling by invitation December 31, 2020 United States, Maryland ... 展开 >> Atavistic Chemotherapy Clinical Trial Bethesda, Maryland, United States, 20814 Mexico Dr. Frank Arguello Cancer Clinic San Jose del Cabo, Baja California Sur, Mexico Instituto de Ciencia y Medicina Genomica Torreon, Coahuila, Mexico 收起 <<

Dapsone 参考文献

[1]Diaz-Ruiz A, Zavala C, Montes S, et al. Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res. 2008;86(15):3410–3419

[2]Roy B, Das RK. Cytogenetic effect of dapsone, an antileprotic drug, in the mouse in vivo system. Int J Lepr Other Mycobact Dis. 1988 Dec;56(4):574-9.

[3]Sheibani M, Nezamoleslami S, Faghir-Ghanesefat H, Emami AH, Dehpour AR. Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats. Cancer Chemother Pharmacol. 2020;85(3):563–571

[4]Coleman MD. Dapsone toxicity: some current perspectives. Gen Pharmacol. 1995;26(7):1461–1467

[5]Coleman MD. Dapsone: modes of action, toxicity and possible strategies for increasing patient tolerance. Br J Dermatol. 1993;129(5):507–513

Dapsone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.14mL

4.03mL

2.01mL

40.27mL

8.05mL

4.03mL

Dapsone 技术信息

CAS号80-08-0
分子式C12H12N2O2S
分子量 248.301
别名 氨苯砜;4,4'-二氨基二苯砜;4，4'-二氨基二苯砜 ;4,4′-Diaminodiphenyl sulfone;DDS;Sulfona;4,4'-Sulfonyldianiline;Diaphenylsulfone;NSC 6091;4,4'-Diaminodiphenyl sulfone;Dapson
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 250 mg/mL(1006.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Dapsone | 4,4′-Diaminodiphenyl sulfone;DDS;Sulfona;4,4'-Sulfonyldianiline;Diaphenylsulfone;NSC 6091;4,4'-Diaminodiphenyl sulfone;Dapson | 氨苯砜;4,4'-二氨基二苯砜;4，4'-二氨基二苯砜 | Other Antibiotics | Antibacterial | AmBeed-信号通路专用抑制剂 | Dapsone 纯度/质量文件 | Dapsone 生物活性 | Dapsone 临床数据 | Dapsone 参考文献 | Dapsone 实验方案 | Dapsone 技术信息

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