产品说明书
Dapsone
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同义名 : | 氨苯砜;4,4'-二氨基二苯砜;4，4'-二氨基二苯砜 ;4,4′-Diaminodiphenyl sulfone;DDS;Sulfona;4,4'-Sulfonyldianiline;Diaphenylsulfone;NSC 6091;4,4'-Diaminodiphenyl sulfone;Dapson |
| CAS号 : | 80-08-0 | |
| 货号 : | A240646 | |
| 分子式 : | C12H12N2O2S | |
| 纯度 : | 98% | |
| 分子量 : | 248.301 | |
| MDL号 : | - | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(1006.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dapsone, an antibiotic drug which is the principal in a multidrug regimen for the treatment of leprosy, is a sulfone with anti-inflammatory and antioxidant immunosuppressive properties[3]. Dapsone is a potent anti-inflammatory and anti-parasitic compound, which is metabolised by cytochrome P-450 to hydroxylamines, which in turn cause methaemoglobinaemia and haemolysis[4]. Dapsone is useful in the treatment of a number of inflammatory conditions which are characterized by neutrophil infiltration. It is the drug of choice for suppression of the symptoms of dermatitis herpetiformis, as it inhibits the process by which neutrophils leave the circulation and migrate to lesional sites[5]. Dapsone antagonized all of the I/R (ischemia-reperfusion) end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, anti-inflammatory, and anti-apoptotic effects[1]. Dapsone exerts cardioprotective effects on doxorubicin-induced cardiotoxicity through its anti-inflammatory and antioxidant mechanism[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00141037 | Kidney Diseases ... 展开 >> Kidney Transplantation Kidney Transplant Renal Transplantation Renal Transplant 收起 << | Phase 1 Phase 2 | Completed | - | United States, Alabama ... 展开 >> University of Alabama - Pediatric Nephrology Birmingham, Alabama, United States, 35233 United States, California Maxine Dunitz Children's Health Center Cedars-Sinai Los Angeles, California, United States, 90048 UCLA - Department of Pediatrics, Division of Nephrology Los Angeles, California, United States, 90095-1752 Stanford University Medical Center, Lucile Packard Children's Hospital Palo Alto, California, United States, 94304 UCSF Children's Hospital San Francisco, California, United States, 94143 United States, Florida University of Florida - Pediatric Nephrology Gainesville, Florida, United States, 32610-0296 United States, Louisiana Children's Hospital of New Orleans-Department of Pediatric Nephrology New Orleans, Louisiana, United States, 70118 United States, Massachusetts Children's Hospital Boston - Division of Nephrology Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Medical Center, C.S. Mott Children's Hospital- Division of Nephrology & Transplantation Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospital - Department of Nephrology Kansas City, Missouri, United States, 64108 United States, Pennsylvania The Children's Hospital of Philadelphia-Department of Nephrology Philadelphia, Pennsylvania, United States, 19104 United States, Washington Children's Hospital & Regional Medical Center - Division of Nephrology Seattle, Washington, United States, 98105 收起 << |
| NCT00141037 | - | Completed | - | - | |
| NCT02366884 | Neoplasms | Phase 2 | Enrolling by invitation | December 31, 2020 | United States, Maryland ... 展开 >> Atavistic Chemotherapy Clinical Trial Bethesda, Maryland, United States, 20814 Mexico Dr. Frank Arguello Cancer Clinic San Jose del Cabo, Baja California Sur, Mexico Instituto de Ciencia y Medicina Genomica Torreon, Coahuila, Mexico 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.03mL 0.81mL 0.40mL |
20.14mL 4.03mL 2.01mL |
40.27mL 8.05mL 4.03mL |
| 参考文献 |
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[4]Coleman MD. Dapsone toxicity: some current perspectives. Gen Pharmacol. 1995;26(7):1461–1467 |