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Dapoxetine HCl

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Chemical Structure| 129938-20-1 同义名 : 达泊西汀 盐酸盐 ;LY-210448 hydrochloride;Dapoxetine (hydrochloride);​(S)-(+)-Dapoxetine;LY-210448;Dapoxetine hydrochloride
CAS号 : 129938-20-1
货号 : A151531
分子式 : C21H24ClNO
纯度 : 97%
分子量 : 341.874
MDL号 : MFCD08272809
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(87.75 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(292.51 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • 5-HT
描述 Dapoxetine hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) known primarily for its use in the study of premature ejaculation (PE)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.63mL

2.93mL

1.46mL

29.25mL

5.85mL

2.93mL
参考文献

[1]Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89.

[2]Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.