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Danicopan {[allProObj[0].p_purity_real_show]}

货号：A1216730 同义名： ACH-4471;ACH-CFDIS

Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Danicopan 化学结构 CAS号：1903768-17-1
Danicopan 化学结构
CAS号：1903768-17-1
Danicopan 3D分子结构
CAS号：1903768-17-1
Danicopan 化学结构 CAS号：1903768-17-1
Danicopan 3D分子结构 CAS号：1903768-17-1
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Danicopan 纯度/质量文件 产品仅供科研

货号：A1216730 标准纯度： {[allProObj[0].p_purity_real_show]}
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Danicopan 生物活性

描述 The complement system provides an important defense against bacteria, fungi, and viruses. Complement factor D (CFD) is a specific serine protease that cleaves its unique substrate and is a promising therapeutic target to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Danicopan (ACH-4471) is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. ACH-4471 potently inhibited hemolysis with IC50 values ranging from 0.0040 μM to 0.027 μM, and blocked the APC-mediated killing by aHUS patient sera at sub-micromolar concentrations, which indicates ACH-4471 has the potential as oral therapeutics for human diseases driven by the alternative pathway of complement, including aHUS[1]. In a second study in PNH patients with poor response to eculizumab (defined as the need of red blood cell transfusion), ACH-4471 was given as add-on treatment on top of standard eculizumab at three different doses (100, 150, or 200 mg thrice a day)[2].

Danicopan 参考文献

[1]Yuan X, Gavriilaki E, Thanassi JA, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017;102(3):466-475.

[2]A Treatment Study of ACH-0144471 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) With Inadequate Response to Eculizumab (PNH)

Danicopan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.61mL

1.72mL

0.86mL

17.23mL

3.45mL

1.72mL

Danicopan 技术信息

CAS号1903768-17-1
分子式C26H23BrFN7O3
分子量 580.408
别名 ACH-4471;ACH-CFDIS;ALXN 2040;ACH-0144471
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 120 mg/mL(206.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Danicopan | 1903768-17-1 | ACH-4471 | ACH4471 | ACH 4471 | Factor D Inhibitor | Immunology/Inflammation | Complement System | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Danicopan 纯度/质量文件 | Danicopan 生物活性 | Danicopan 参考文献 | Danicopan 实验方案 | Danicopan 技术信息

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