货号:A166104 同义名: D-APV;D-2-Amino-5-phosphonovaleric acid
D-AP5(D-APV)是一种选择性和竞争性的NMDA受体拮抗剂,其Kd为1.4 μM。D-AP5抑制了NMDA受体的谷氨酸位点的谷氨酸结合。
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产品名称 | NMDA receptor ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Empirical Formula | ✔ | 97% | |||||||||||||||||
Dizocilpine maleate |
+++
NMDA receptor, Kd: 37.2 nM | 99%+ | |||||||||||||||||
Felbamate |
+
NMDAR, IC50: 1.8 mM | 98% | |||||||||||||||||
(-)-Dizocilpine maleate |
++++
NMDA receptor, Ki: 30.5 nM | 98% | |||||||||||||||||
Ifenprodil tartrate |
+++
NMDA Receptor, IC50: 0.3 μM | 98% | |||||||||||||||||
Spermidine | ✔ | Autophagy | 98% GC | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 inhibits the glutamate binding site of NMDA receptors[1][2]. |
Animal study | D-AP5, an antagonist of NMDA receptors, has been observed to disrupt spatial learning and long-term potentiation (LTP) in a dose-dependent manner when administered chronically via intraventricular infusion. Notably, intracerebral D-AP5 does not cause sensorimotor disturbances when it prevents spatial learning[2]. Furthermore, D-AP5 treatment leads to a gradual decrease in swimming speed across trials. It also induces sensorimotor disruptions in spatial tasks, which worsen as the learning impairment progresses. In delayed matching-to-place water maze tests, rats receiving D-AP5 exhibit a delay-related decline in spatial memory[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM | 5.07mL 1.01mL 0.51mL | 25.36mL 5.07mL 2.54mL | 50.73mL 10.15mL 5.07mL |
CAS号 | 79055-68-8 |
分子式 | C5H12NO5P |
分子量 | 197.126 |
别名 | D-APV;D-2-Amino-5-phosphonovaleric acid |
运输 | 蓝冰 |
存储条件 | 液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Store in freezer, under -20°C |
溶解度 | H2O: 2 mg/mL(10.15 mM),配合低频超声助溶 |
动物实验配方 |