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D-AP5

货号:A166104 同义名: D-APV;D-2-Amino-5-phosphonovaleric acid

D-AP5(D-APV)是一种选择性和竞争性的NMDA受体拮抗剂,其Kd为1.4 μM。D-AP5抑制了NMDA受体的谷氨酸位点的谷氨酸结合。

D-AP5 化学结构 CAS号:79055-68-8
D-AP5 化学结构
CAS号:79055-68-8
D-AP5 3D分子结构
CAS号:79055-68-8
D-AP5 化学结构 CAS号:79055-68-8
D-AP5 3D分子结构 CAS号:79055-68-8
规格 价格 库存 数量
1mg ¥270 咨询
5mg ¥844 咨询
10mg ¥1450 咨询
25mg ¥3623 咨询
50mg ¥7243 咨询
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D-AP5 纯度/质量文件 产品仅供科研

货号:A166104 标准纯度:
批次查询: 批次纯度:

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产品名称 NMDA receptor 其他靶点 纯度
Empirical Formula 97%
Dizocilpine maleate +++

NMDA receptor, Kd: 37.2 nM

99%+
Felbamate +

NMDAR, IC50: 1.8 mM

98%
(-)-Dizocilpine maleate ++++

NMDA receptor, Ki: 30.5 nM

98%
Ifenprodil tartrate +++

NMDA Receptor, IC50: 0.3 μM

98%
Spermidine Autophagy 98% GC
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

D-AP5 生物活性

描述 D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 inhibits the glutamate binding site of NMDA receptors[1][2].

D-AP5 动物研究

Animal study D-AP5, an antagonist of NMDA receptors, has been observed to disrupt spatial learning and long-term potentiation (LTP) in a dose-dependent manner when administered chronically via intraventricular infusion. Notably, intracerebral D-AP5 does not cause sensorimotor disturbances when it prevents spatial learning[2]. Furthermore, D-AP5 treatment leads to a gradual decrease in swimming speed across trials. It also induces sensorimotor disruptions in spatial tasks, which worsen as the learning impairment progresses. In delayed matching-to-place water maze tests, rats receiving D-AP5 exhibit a delay-related decline in spatial memory[3].

D-AP5 参考文献

[1]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75.

[2]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.

[3]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.

D-AP5 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.07mL

1.01mL

0.51mL

25.36mL

5.07mL

2.54mL

50.73mL

10.15mL

5.07mL

D-AP5 技术信息

CAS号79055-68-8
分子式C5H12NO5P
分子量 197.126
别名 D-APV;D-2-Amino-5-phosphonovaleric acid
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

H2O: 2 mg/mL(10.15 mM),配合低频超声助溶

动物实验配方
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