Empirical Formula | 犬尿喹啉酸 | Quinurenic acid | iGluR/α7 nAChR Antagonist

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犬尿喹啉酸水合物 /Empirical Formula {[allProObj[0].p_purity_real_show]}

货号：A141971 同义名： 犬尿喹啉酸 / Quinurenic acid;Kynurenic acid

Kynurenic Acid is a broad spectrum glutamatergic antagonist which can antagonize NMDA, kainate and AMPA receptors.

Empirical Formula 化学结构
CAS号：492-27-3

Empirical Formula 3D分子结构
CAS号：492-27-3

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货号：A141971 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Empirical Formula 生物活性

靶点

NMDA receptor

描述

Kynurenic acid (KYNA) is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N‐methyl‐D‐aspartate (NMDA) which regulate neuronal excitability and plasticity, brain development and behaviour^[3]. Peripheral administration of kynurenic acid, at a dose that caused plasma levels to increase 430-fold, resulted in only 4-fold increases in striatal ECF(extracellular fluid) concentrations^[4]. KYNA has a significant protective effect on liver injury induced by thioacetamide (TAA)^[5].

Empirical Formula 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03557684	Depression	Early Phase 1	Recruiting	July 31, 2020	United States, California ... 展开 >> UCLA Cousins Center for Psychoneuroimmunology Recruiting Los Angeles, California, United States, 90095 Contact: Gracie Pineda 310-825-8425 grpineda@g.ucla.edu Principal Investigator: Joshua H Cho, MD, PhD 收起 <<
NCT00573300	-		Completed	-	United States, Massachusetts ... 展开 >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 收起 <<
NCT02234752	Schizophrenia ... 展开 >> Schizoaffective Disorder 收起 <<	Phase 2	Terminated(Funding no longer a... 展开 >>vailable and PI no longer working at the institution) 收起 <<	-	United States, Maryland ... 展开 >> Sheppard Pratt Health System Baltimore, Maryland, United States, 21204 收起 <<

Empirical Formula 参考文献

[1]Sekine A, Okamoto M, et al. Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro. Springerplus. 2015 Feb 1;4:48.

[2]Di Serio C, Cozzi A, et al. Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro. Cell Mol Neurobiol. 2005 Sep;25(6):981-93.

[3]Stone TW. Does kynurenic acid act on nicotinic receptors? An assessment of the evidence. J Neurochem. 2020 Mar;152(6):627-649. doi: 10.1111/jnc.14907. Epub 2019 Nov 24. PMID: 31693759; PMCID: PMC7078985.

[4]Swartz KJ, During MJ, Freese A, Beal MF. Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors. J Neurosci. 1990 Sep;10(9):2965-73. doi: 10.1523/JNEUROSCI.10-09-02965.1990. PMID: 2168940; PMCID: PMC6570241.

[5]Marciniak S, Wnorowski A, Smolińska K, Walczyna B, Turski W, Kocki T, Paluszkiewicz P, Parada-Turska J. Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats. Anal Cell Pathol (Amst). 2018 Sep 20;2018:1270483. doi: 10.1155/2018/1270483. PMID: 30327755; PMCID: PMC6171262.

Empirical Formula 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.29mL

1.06mL

0.53mL

26.43mL

5.29mL

2.64mL

52.86mL

10.57mL

5.29mL

Empirical Formula 技术信息

CAS号	492-27-3
分子式	C₁₀H₇NO₃
分子量	189.167

别名	犬尿喹啉酸 ;Quinurenic acid;Kynurenic acid;Kynuronic acid;Kynurenate
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 8 mg/mL(42.29 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

0.1 M NaOH: 10 mg/mL(52.86 mM)，配合低频超声，并调节pH至9

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03557684	Depression	Early Phase 1	Recruiting	July 31, 2020	United States, California ... 展开 >> UCLA Cousins Center for Psychoneuroimmunology Recruiting Los Angeles, California, United States, 90095 Contact: Gracie Pineda 310-825-8425 grpineda@g.ucla.edu Principal Investigator: Joshua H Cho, MD, PhD 收起 <<
NCT00573300	-		Completed	-	United States, Massachusetts ... 展开 >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 收起 <<
NCT02234752	Schizophrenia ... 展开 >> Schizoaffective Disorder 收起 <<	Phase 2	Terminated(Funding no longer a... 展开 >>vailable and PI no longer working at the institution) 收起 <<	-	United States, Maryland ... 展开 >> Sheppard Pratt Health System Baltimore, Maryland, United States, 21204 收起 <<
NCT03285399	-		Completed	-	Nepal ... 展开 >> Siddhi Memorial Hospital (SMH),Bhelukhel, Bhimsensthan Bhaktapur, Nepal, P.O.Box 40 收起 <<
NCT02234752	-		Terminated(Funding no longer a... 展开 >>vailable and PI no longer working at the institution) 收起 <<	-	-
NCT03513822	Neuralgia Chr... 展开 >>onic Pain Inflammation 收起 <<	Phase 3	Recruiting	November 2018	France ... 展开 >> Raymond Poincaré Hospital Recruiting Garches, Hauts De Seine, France, 92380 Contact: Cyril QUEMENEUR, Resident 0033681193981 c.quemeneur@gmx.com Contact: Valeria Martinez, MD, PhD 0033601819222 valeria.martinez@aphp.fr 收起 <<
NCT03539835	Cancer	Not Applicable	Recruiting	September 2019	United States, Georgia ... 展开 >> Winship Cancer Institute Recruiting Atlanta, Georgia, United States, 30322 Contact: Monica Serra, MD 404-727-6123 monica.christine.serra@emory.edu 收起 <<
NCT02992899	PostTraumatic Stress Disorder	Not Applicable	Recruiting	July 2019	United States, Georgia ... 展开 >> Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Stacy Ladd 404-712-2014 sladd2@emory.edu 收起 <<
NCT03125083	Skin Restricted Lupus ... 展开 >> Psychiatric Disorders 收起 <<	Not Applicable	Recruiting	December 2018	France ... 展开 >> CHU Clermont-Ferrand Recruiting Clermont-Ferrand, France, 63003 Contact: Patrick LACARIN 04 73 75 11 95 placarin@chu-clermontferrand.fr Principal Investigator: Isabelle JALENQUES 收起 <<
NCT01975584	Schizophrenia ... 展开 >> Schizoaffective Disorder 收起 <<	Not Applicable	Completed	-	United States, Maryland ... 展开 >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 收起 <<
NCT03014518	-		Recruiting	August 2019	United States, Ohio ... 展开 >> The Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Tatiana Falcone, M.D. 216-444-7459 falcont1@ccf.org 收起 <<
NCT01304355	-		Unknown	January 2012	Ireland ... 展开 >> Cork University Hospial Recruiting Cork, Ireland Contact: Gerard Clarke, PhD 00353214901415 g.clarke@ucc.ie Principal Investigator: Gerard Clarke, PhD Principal Investigator: Timothy G Dinan, Professor Principal Investigator: John F Cryan, PhD University College Cork Recruiting Cork, Ireland Contact: Gerard Clarke, PhD 00353214901415 g.clarke@ucc.ie Principal Investigator: Gerard Clarke, PhD Principal Investigator: Timothy G Dinan, Professor Principal Investigator: John F Cryan, PhD 收起 <<
NCT02067975	Schizophrenia	Phase 2 Phase 3	Recruiting	December 2018	United States, Maryland ... 展开 >> Maryland Psychiatric Research Center Recruiting Catonsville, Maryland, United States, 21228 Principal Investigator: Robert W. Buchanan, M.D. 收起 <<
NCT02340325	Cicatrix Cica... 展开 >>trix, Hypertrophic Keloid 收起 <<	Phase 1	Completed	-	Canada, British Columbia ... 展开 >> BCPFF Burn & Wound Healing Lab Vancouver, British Columbia, Canada, V5Z1M9 收起 <<
NCT03583554	Healthy	Phase 1 Phase 2	Recruiting	March 31, 2019	United States, Texas ... 展开 >> Michael E. DeBakey VA Medical Center Recruiting Houston, Texas, United States, 77030 Contact: Marijn Lijffijt, PhD 713-798-5642 marijn.lijffijt@bcm.edu Sub-Investigator: Sanjay J. Mathew, MD Sub-Investigator: Alan C. Swann, MD 收起 <<
NCT01558570	-		Completed	-	United States, Maryland ... 展开 >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 收起 <<

犬尿喹啉酸水合物 /Empirical Formula {[allProObj[0].p_purity_real_show]}

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Empirical Formula 生物活性

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全球学术期刊中引用的产品

Empirical Formula 质控信息

Empirical Formula 生物活性

Empirical Formula 临床研究

Empirical Formula 参考文献

Empirical Formula 实验方案

Empirical Formula 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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