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皮质酮 /Corticosterone {[allProObj[0].p_purity_real_show]}

货号：A384721 同义名： 皮质酮 / 17-Deoxycortisol;11β,21-Dihydroxyprogesterone

Corticosterone（标准品）是皮质酮的分析标准品，适用于研究和分析应用。这种口服活性的糖皮质激素由肾上腺皮质产生，在调节边缘系统（包括海马、前额叶皮质和杏仁核）的神经功能中起关键作用。它通过SGK诱导的GDI磷酸化增加Rab介导的AMPAR膜运输，干扰树突状细胞成熟，并表现出显著的免疫抑制作用。

Corticosterone 化学结构 CAS号：50-22-6
Corticosterone 化学结构
CAS号：50-22-6
Corticosterone 3D分子结构
CAS号：50-22-6
Corticosterone 化学结构 CAS号：50-22-6
Corticosterone 3D分子结构 CAS号：50-22-6
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Corticosterone 纯度/质量文件 产品仅供科研

货号：A384721 标准纯度： {[allProObj[0].p_purity_real_show]}
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Corticosterone 生物活性

描述 Both mineralocorticoid receptors and glucocorticoid receptors belong to the family of nuclear receptors. They are respectively encoded by the Nuclear Receptor Subfamily 3 Group C Member 2 and Member 1. The mineralocorticoid receptors mediate aldosterone actions on salt and water balance within restricted target cells and thus function as ligand-dependent transcription factors that bind to mineralocorticoid response elements in order to transactivate target genes. The glucocorticoid receptors function both as transcription factors that bind to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as regulators of other transcription factors. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. Corticosterone can act as ligand of both mineralocorticoid receptors and glucocorticoid receptors. In cultured PFC pyramidal neurons, 30 min treatment of 100 nM corticosterone enhanced mEPSC amplitude. In an immunocytochemical approach, 30 min treatment of 100 nM corticosterone increased neuron surface GluR1 cluster density, cluster size and cluster fluorescence intensity[3]. Revealed by a co-immunoprecipitation assay, 30 min treatment of 100 nM corticosterone increased the formation of GDI-Rab4 complex[3]. HT22 cells treated by 400 μM corticosterone for 3h resulted in remarkable increase of nuclear localized glucocorticoid receptor[4]. In an ex vivo experiment, corticosterone inhibited [3H]MMP+ uptake in 3V-MH tissue with an IC50 of 0.152 μM[5].
作用机制 Corticosterone is an adrenocortical steroid can act as ligand of both mineralocorticoid receptors and glucocorticoid receptors. Corticosterone may exert its actions by binding directly to receptors[6].

Corticosterone 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02054208 Alzheimer's Disease Phase 1 Phase 2 Recruiting July 2019 Korea, Republic of ... 展开 >> Samsung Medical Center Recruiting Seoul, Korea, Republic of Contact: Yunkyung Choi, MD    82-2-3410-6486    yk221.choi@samsung.com    Principal Investigator: Duk L. Na, MD 收起 <<
NCT03172117 Alzheimer's Disease Phase 1 Phase 2 Recruiting December 31, 2021 Korea, Republic of ... 展开 >> Samsung Medical Center Recruiting Seoul, Korea, Republic of Contact: Heejin Choi, MD    +82-2-3410-1947    evekhj@gmail.com    Principal Investigator: Duk L Na, MD 收起 <<
NCT00667810 Alzheimer Disease Phase 3 Terminated(The study was termi... 展开 >>nated on August 6, 2012, because 2 large Phase 3 studies showed no clinical benefit. This decision was not based on any new safety concerns.) 收起 << - -

Corticosterone 参考文献

[1]Pinson SE, Wilson JL, et al. Timing matters: corticosterone injections 4 h before ovulation bias sex ratios towards females in chickens. J Comp Physiol B. 2015 Jul;185(5):539-46.

[2]Ebada ME, Latif LM, et al. Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice. Rom J Morphol Embryol. 2014;55(4):1303-16.

[3] Liu W, Yuen EY, Yan Z. The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex. J Biol Chem. 2010 Feb 26;285(9):6101-8.

[4]Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S. Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure. Animals (Basel). 2019 Sep 14;9(9):682.

[5]Gasser PJ, Lowry CA, Orchinik M. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-66.

[6]Bering T, Hertz H, Rath MF. Rhythmic Release of Corticosterone Induces Circadian Clock Gene Expression in the Cerebellum. Neuroendocrinology. 2020;110(7-8):604-615.

Corticosterone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.43mL

2.89mL

1.44mL

28.86mL

5.77mL

2.89mL

Corticosterone 技术信息

CAS号50-22-6
分子式C21H30O4
分子量 346.461
别名 皮质酮 ;17-Deoxycortisol;11β,21-Dihydroxyprogesterone;CCRIS 6753;BRN-233960;BRN 2339601;11β,21-DHP;NSC-9705;Kendall's compound B
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 105 mg/mL(303.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 12 mg/mL(34.64 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

SC 40% DMSO+60% Corn oil 20 mg/mL clear

IP 5%DMSO+95%H2O 1 mg/mL clear

Tags: Corticosterone | 17-Deoxycortisol;11β,21-Dihydroxyprogesterone;CCRIS 6753;BRN-233960;BRN 2339601;11β,21-DHP;NSC-9705;Kendall's compound B | 皮质酮 | Progesterone | MAT | AmBeed-信号通路专用抑制剂 | Corticosterone 纯度/质量文件 | Corticosterone 生物活性 | Corticosterone 临床数据 | Corticosterone 参考文献 | Corticosterone 实验方案 | Corticosterone 技术信息

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