Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine, with IC50 value of 23µM in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Conoidin A is an inhibitor of host cell invasion by the protozoan parasite Toxoplasma gondii[3]. Inhibition of PRDXs by conoidin A (1, 10, or 100 µM) significantly decreased the oxidized form of peroxiredoxins (PRDXs-SO3) in spermatozoa[4]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease. Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation. Furthermore, an increase in the infarct size presented of the MI/R (myocardial ischaemia/reperfusion) group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishes the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo[5].
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