产品说明书
Conoidin A
 |
同义名 : | - |
| CAS号 : | 18080-67-6 | |
| 货号 : | A710657 | |
| 分子式 : | C10H8Br2N2O2 | |
| 纯度 : | 98+% | |
| 分子量 : | 347.991 | |
| MDL号 : | MFCD00186742 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 15 mg/mL(43.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Conoidin A is an inhibitor of host cell invasion by the protozoan parasite Toxoplasma gondii[3]. Inhibition of PRDXs by conoidin A (1, 10, or 100 µM) significantly decreased the oxidized form of peroxiredoxins (PRDXs-SO3) in spermatozoa[4]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease. Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation. Furthermore, an increase in the infarct size presented of the MI/R (myocardial ischaemia/reperfusion) group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishes the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.87mL 0.57mL 0.29mL |
14.37mL 2.87mL 1.44mL |
28.74mL 5.75mL 2.87mL |
| 参考文献 |
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