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Conoidin A

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Chemical Structure| 18080-67-6 同义名 : -
CAS号 : 18080-67-6
货号 : A710657
分子式 : C10H8Br2N2O2
纯度 : 98+%
分子量 : 347.991
MDL号 : MFCD00186742
存储条件:

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 15 mg/mL(43.1 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Conoidin A is an inhibitor of host cell invasion by the protozoan parasite Toxoplasma gondii[3]. Inhibition of PRDXs by conoidin A (1, 10, or 100 µM) significantly decreased the oxidized form of peroxiredoxins (PRDXs-SO3) in spermatozoa[4]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease. Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation. Furthermore, an increase in the infarct size presented of the MI/R (myocardial ischaemia/reperfusion) group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishes the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.87mL

0.57mL

0.29mL

14.37mL

2.87mL

1.44mL

28.74mL

5.75mL

2.87mL

参考文献

[1]Haraldsen JD, Liu G, Botting CH, Walton JG, Storm J, Phalen TJ, Kwok LY, Soldati-Favre D, Heintz NH, Müller S, Westwood NJ, Ward GE. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048. doi: 10.1039/B901735F. PMID: 21359112; PMCID: PMC3043594.

[2] Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22;20(8):991-1001. doi: 10.1016/j.chembiol.2013.06.011. Epub 2013 Jul 25. PMID: 23891152; PMCID: PMC3755041.

[3]Haraldsen JD, Liu G, Botting CH, Walton JG, Storm J, Phalen TJ, Kwok LY, Soldati-Favre D, Heintz NH, Müller S, Westwood NJ, Ward GE. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048

[4]Ryu DY, Kim KU, Kwon WS, Rahman MS, Khatun A, Pang MG. Peroxiredoxin activity is a major landmark of male fertility. Sci Rep. 2017 Dec 7;7(1):17174

[5]Wei B, Lin Q, Ji YG, Zhao YC, Ding LN, Zhou WJ, Zhang LH, Gao CY, Zhao W. Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II. Br J Pharmacol. 2018 Aug;175(16):3315-3332