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Coelenterazine
腔肠素 /Coelenterazine
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货号：A544127
同义名：
Luciferin (Oplophorus);Preluciferin (Watasenia)
Coelenterazine 是许多发光酶的底物，作为发光素，是一种发光分子，广泛存在于八个门的水生生物中。
Coelenterazine 化学结构
Coelenterazine 3D分子结构
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Coelenterazine 纯度/质量文件 产品仅供科研
货号：A544127
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Coelenterazine 质控信息
Coelenterazine 生物活性
描述
Coelenterazine is a luciferin found in many aquatic organisms across eight phyla. It is luminophore of the aequorin complex which is oxidized by oxygen to illuminate at 465nm. It is used for bioluminescence, such as measuring the intracellular calcium concentration[6] [7] in vivo bioluminescence imaging[8]
Coelenterazine 动物研究
Dose
Mice: 0.07 mg/kg - 3.5 mg/kg[4] [5]
Administration
i.v.
Coelenterazine 参考文献
[1] Pandey D, Fulton DJ, et al. Molecular regulation of NADPH oxidase 5 via the MAPK pathway. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1336-44.
[2] Ritsick DR, Edens WA, et al. Nox regulation of smooth muscle contraction. Free Radic Biol Med. 2007 Jul 1;43(1):31-8. Epub 2007 Mar 12.
[3] Gentschev I, Stritzker J, et al. Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent. Cancer Gene Ther. 2009 Apr;16(4):320-8.
[4] Bhaumik S, Gambhir SS, et al. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):377-82. Epub 2001 Dec 18.
[5] Bronsart LL, Stokes C, et al. Chemiluminescence Imaging of Superoxide Anion Detects Beta-Cell Function and Mass. PLoS One. 2016 Jan 11;11(1):e0146601.
[6] Pandey D, Fulton DJ. Molecular regulation of NADPH oxidase 5 via the MAPK pathway. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1336-44. doi: 10.1152/ajpheart.01163.2010. Epub 2011 Feb 4. PMID: 21297032; PMCID: PMC3075021.
[7] Ritsick DR, Edens WA, Finnerty V, Lambeth JD. Nox regulation of smooth muscle contraction. Free Radic Biol Med. 2007 Jul 1;43(1):31-8. doi: 10.1016/j.freeradbiomed.2007.03.006. Epub 2007 Mar 12. PMID: 17561091; PMCID: PMC1989158.
[8] Gentschev I, Stritzker J, Hofmann E, Weibel S, Yu YA, Chen N, Zhang Q, Bullerdiek J, Nolte I, Szalay AA. Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent. Cancer Gene Ther. 2009 Apr;16(4):320-8. doi: 10.1038/cgt.2008.87. Epub 2008 Oct 24. PMID: 18949014.
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Coelenterazine 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.36mL
0.47mL
0.24mL
11.81mL
2.36mL
1.18mL
23.61mL
4.72mL
2.36mL
Coelenterazine 技术信息
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