Cloxacillin Sodium Salt Monohydrate是一种口服有效的抗菌剂和 β-lactamase 抑制剂，IC50 为 0.04 µM，能够抑制金黄色葡萄球菌引起的炎症反应。
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
USD 200+
Cloxacillin Sodium Salt Monohydrate 化学结构 CAS号：7081-44-9
Cloxacillin Sodium Salt Monohydrate 3D分子结构 CAS号：7081-44-9
Cloxacillin (Sodium Monohydrate), a semisynthetic penicillin is a potent inhibitor of most penicillinase-producing Staphylococci. Use of high doses of Cloxacillin for 6 weeks is recommended for the treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus (MSSA)[2]. After single IV administration of sodium cloxacillin in calves, its half-life, body clearance, and volume of distribution were 19.5 ± 12.8 minutes, 18.3 ± 2.2 ml/min/kg, and 496 ± 290 ml/kg, respectively[3]. During treatment of endocarditis caused by a tolerant strain, the reduction of bacterial numbers in the infected vegetations decreased significantly with increasing doses of cloxacillin. Furthermore, continuous administration of cloxacillin was significantly less effective in reducing bacterial numbers in the vegetations for the tolerant strain than for the non-tolerant strain[4].
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