Cloxacillin Sodium Salt Monohydrate
产品说明书
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同义名 : | 氯唑西林钠一水合物 ;Cloxacillin Sodium;Cloxacillin sodium monohydrate |
| CAS号 : | 7081-44-9 | |
| 货号 : | A263441 | |
| 分子式 : | C19H19ClN3NaO6S | |
| 纯度 : | 98% | |
| 分子量 : | 475.878 | |
| MDL号 : | MFCD00150735 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(220.64 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(105.07 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Cloxacillin (Sodium Monohydrate), a semisynthetic penicillin is a potent inhibitor of most penicillinase-producing Staphylococci. Use of high doses of Cloxacillin for 6 weeks is recommended for the treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus (MSSA)[2]. After single IV administration of sodium cloxacillin in calves, its half-life, body clearance, and volume of distribution were 19.5 ± 12.8 minutes, 18.3 ± 2.2 ml/min/kg, and 496 ± 290 ml/kg, respectively[3]. During treatment of endocarditis caused by a tolerant strain, the reduction of bacterial numbers in the infected vegetations decreased significantly with increasing doses of cloxacillin. Furthermore, continuous administration of cloxacillin was significantly less effective in reducing bacterial numbers in the vegetations for the tolerant strain than for the non-tolerant strain[4]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.10mL 0.42mL 0.21mL |
10.51mL 2.10mL 1.05mL |
21.01mL 4.20mL 2.10mL |
| 参考文献 |
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