There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Calcium-sensing receptor (CaSR), which belongs to the G protein-coupled receptor superfamily, is responsible for the regulation of systemic Ca2+ metabolism. Cinacalcet is a calcimimetic that allosterically increases the sensitivity and responsiveness of CaSR to Ca2+. It activates the wild-type CaSR signaling in cellular proliferation and PI hydrolysis assays with pEC50 values of 7.6 and 7.3, respectively[3]. When primary cultured human parathyroid cells were incubated with 0.5 mM extracellular Ca2+, Cinacalcet from 0 – 1000 nM additionally suppressed the secretion of parathyroid hormone at a dose-dependent manner[4]. Cinacalcet at 30 – 1000 nM had no effect on osteoclastic formation or resorption in osteoclastic cells cultured in calcium-containing medium with the concentration of 1.6 or 6.1 mM[5]. Oral administration of primary hyperparathyroidism mice with 1 mg/g Cinacalcet for 10 days led to significantly reduced levels of parathyroid and Ca in serum. The uptake of 5-Bromo-2'-deoxyuridine was also significantly decreased in mice following the administration of Cinacalcet compared to the untreated ones[6].
Italy
... 展开 >> Ospedale generale regionale "Miulli"
Acquaviva delle Fonti, Italy, 70021
Ospedale Maggiore Policlinico Mangiagalli e Regina Elena
Milano, Italy, 20122
Spain
Hospital Universitario Marquès de Valdecilla
Santander, Cantabria, Spain, 39008 收起 <<
France
... 展开 >> Centre Hospitalier Général
Soissons, Aisne, France, 02009
Centre Hospitalier
Lisieux, Calvados, France, 14100
ALURAD
Limoges, Limousin, France, 87042
Centre Hospitalier Universitaire
Reims, Marne, France, 51092
Association Régionale Promotion Dialyse à domicile (ARPDD)
Reims, Marne, France
Association pour le Développement de l'Hémodialyse
Hénin-Beaumont, Nord-Pas de Calais, France, 62110
Polyclinique de la Louvière
Lille, Nord, France, 59000
CHRU
Lille, Nord, France, 59037
Hôpital Victor Provo
Roubaix, Nord, France, 59056
Centre Hospitalier Général
Valenciennes, Nord, France, 59322
Centre Hospitalier Général
Beauvais, Oise, France, 60000
Clinique Saint Côme
Compiegne, Oise, France, 60200
Centre Hospitalier Général
Creil, Oise, France, 60100
Clinique du Bois Bernard
Bois Bernard, Pas de calais, France, 62320
Centre Hospitalier
Boulogne sur mer, Pas de calais, France, 62200
Centre Hospital-Universitaire d'Amiens
Amiens, Picardie, France, 80054
Clinique de l'Europe
Rouen, Seine maritime, France, 76040
Centre Hospitalier
Cambrai, France, 59407 收起 <<
Terminated(Study was suspended... 展开 >> in agreement between sponsor and FDA due to concerns about the study design after a fatality had occurred in the presence of hypocalcemia.) 收起 <<
Terminated(Study was suspended... 展开 >> in agreement between sponsor and FDA due to concerns about the study design after a fatality had occurred in the presence of hypocalcemia.) 收起 <<
Hong Kong
... 展开 >> Queen Mary Hospital and Tung Wah Hospital
Recruiting
Hong Kong, Hong Kong, 0000
Contact: Angela YM Wang, MD, PhD 852-22554949 aymwang@hku.hk
Principal Investigator: Angela YM Wang, MD, PhD
Sub-Investigator: Wai-Kei Lo, FRCP 收起 <<
United States, Missouri
... 展开 >>
Section of Pediatric Nephrology, Children's Mercy Hospitals and Clinics
Recruiting
Kansas City, Missouri, United States, 64108
Principal Investigator: Rachel Levy-Olomucki, MD 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Hospital
Seoul, Korea, Korea, Republic of, 110-744
Kyungpook National University
Daegu, Korea, Republic of
Gil Hospital
Incheon, Korea, Republic of
Hallym University Sacred Hospital
Pyungchon, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam, Korea, Republic of
Eulji University
Seoul, Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of 收起 <<
United States, New York
... 展开 >>
Montefiore Medical Center
Recruiting
Bronx, New York, United States, 10467
Principal Investigator: Maria Coco, MD,MS 收起 <<
Malaysia
... 展开 >> Clinical Research Centre, Penang Hospital
George Town, Penang, Malaysia, 10990
Penang Hospital
Not yet recruiting
George Town, Penang, Malaysia, 10990
Contact: Ong Loke Meng, FRCS 00 604 2225333 ext 767 onglm@crc.gov.my 收起 <<
United States, California
... 展开 >>
Research Site
Los Angeles, California, United States, 90095
Research Site
San Francisco, California, United States, 94143
United States, Kentucky
Research Site
Louisville, Kentucky, United States, 40202
United States, Missouri
Research Site
Kansas City, Missouri, United States, 64108
Germany
Research Site
Heidelberg, Germany, 69120
United Kingdom
Research Site
Bristol, United Kingdom, BS2 8BJ
Research Site
Glasgow, United Kingdom, G3 8SJ
Research Site
Leeds, United Kingdom, LS1 3EX
Research Site
Manchester, United Kingdom, M13 9WL
Research Site
Nottingham, United Kingdom, NG7 2UH 收起 <<
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