Ciliobrevin A 是一种选择性的 dynein ATPase 抑制剂，能够抑制微管滑动和细胞内运输。Ciliobrevin A 主要用于细胞骨架、分子马达蛋白和细胞动力学的研究。
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HazMat fee for 500 gram (Estimated)
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USD 15-60
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USD 80+
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Accessible (Haz class 3, 4, 5 or 8), International
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens[3]. Ciliobrevin A is an Hh signaling pathway inhibitor with an IC50 value less than 10 μM[4]. Ciliobrevin A prevents an increase in the FLAG-Gli2 full-length/repressor ratio upon Shh stimulation. Ciliobrevin A also perturbs primary cilia formation in the Shh-LIGHT2FLAG-Gli1 cells and promotes accumulation of FLAG-Gli1 at the distal tip of this organelle. Ciliobrevin A significantly inhibits the proliferation of these neuronal progenitors, as measured by histone H3 phosphorylation (pH3) levels, and reduces cellular levels of cyclin D1 protein and Gli1, Gli2, and N-Myc transcripts in the CGNPs[4]. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. Hh downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9)[5]. In zebrafish models, HPI-4 can effectively prevent pancreatic fibrosis and destruction[6].
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