西司他丁 /Cilastatin
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货号：A371776
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MK0791
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.
Cilastatin 化学结构
Cilastatin 3D分子结构
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Cilastatin 纯度/质量文件 产品仅供科研
货号：A371776
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Cilastatin 质控信息
Cilastatin 生物活性
描述
Membrane dipeptidase is a glycoprotein involved in the hydrolysis of dipeptides and dehydropeptides. Cilastatin is a reversible, competitive inhibitor of dehydropeptidase I, a renal dipeptidase, with an IC50 value of 0.1μM. It also inhibits bacterial metallo-β-lactamase enzyme CphA with an IC50 value of 178 ± 11μM[4] [5] S. aureus , E. coli , and P. aeruginosa infection[6]
Cilastatin 参考文献
[1] The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterialmetallo-beta-lactamase enzyme CphA. Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31.
[2] Blanca Humanes, et al. Protective Effects of Cilastatin Against Vancomycin-Induced Nephrotoxicity. Biomed Res Int. 2015;2015:704382.
[3] P J Petersen, et al. In Vitro and in Vivo Activities of LJC10,627, a New Carbapenem With Stability to Dehydropeptidase I. Antimicrob Agents Chemother. 1991 Jan;35(1):203-7.
[4] Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ. The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA. Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31. doi: 10.1128/AAC.39.7.1629
[5] Humanes B, Jado JC, Camaño S, López-Parra V, Torres AM, Álvarez-Sala LA, Cercenado E, Tejedor A, Lázaro A. Protective Effects of Cilastatin against Vancomycin-Induced Nephrotoxicity. Biomed Res Int. 2015;2015:704382. doi: 10.1155/2015/704382
[6] Petersen PJ, Jacobus NV, Weiss WJ, Testa RT. In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I. Antimicrob Agents Chemother. 1991 Jan;35(1):203-7. doi: 10.1128/AAC.35.1.203
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Cilastatin 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.79mL
0.56mL
0.28mL
13.95mL
2.79mL
1.39mL
27.90mL
5.58mL
2.79mL
Cilastatin 技术信息
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