产品说明书
Cilastatin
 |
同义名 : | MK0791 |
| CAS号 : | 82009-34-5 | |
| 货号 : | A371776 | |
| 分子式 : | C16H26N2O5S | |
| 纯度 : | 95% | |
| 分子量 : | 358.453 | |
| MDL号 : | MFCD00867379 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(292.93 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 12 mg/mL(33.48 mM)，配合低频超声，并水浴加热至45℃助溶 1M NaOH: 100 mg/mL(278.98 mM)，配合低频超声，并调节pH至11 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Membrane dipeptidase is a glycoprotein involved in the hydrolysis of dipeptides and dehydropeptides. Cilastatin is a reversible, competitive inhibitor of dehydropeptidase I, a renal dipeptidase, with an IC50 value of 0.1μM. It also inhibits bacterial metallo-β-lactamase enzyme CphA with an IC50 value of 178 ± 11μM[4]. Cilastatin at 3 and 6 mg/mL significantly reduced the detachment of renal proximal tubular epithelial cells (RPTECs). Treatment with cilastatin also significantly ameliorated vancomycin-induced nuclear apoptosis of RPTECs[5]. Cilastatin in combination with imipenem protected female CD-1 mice from S. aureus, E. coli, and P. aeruginosa infection[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.79mL 0.56mL 0.28mL |
13.95mL 2.79mL 1.39mL |
27.90mL 5.58mL 2.79mL |
| 参考文献 |
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