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首页 / 药物研究 / 药物分析 / 药物标准品 / Chenodeoxycholic acid

鹅去氧胆酸 /Chenodeoxycholic acid {[allProObj[0].p_purity_real_show]}

货号：A342210 同义名： CDCA

Chenodeoxycholic acid是一种天然存在的人类胆汁酸，能够抑制肝脏中胆固醇的产生及肠道中的吸收。

Chenodeoxycholic acid 化学结构 CAS号：474-25-9
Chenodeoxycholic acid 化学结构
CAS号：474-25-9
Chenodeoxycholic acid 3D分子结构
CAS号：474-25-9
Chenodeoxycholic acid 化学结构 CAS号：474-25-9
Chenodeoxycholic acid 3D分子结构 CAS号：474-25-9
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Chenodeoxycholic acid 纯度/质量文件 产品仅供科研

货号：A342210 标准纯度： {[allProObj[0].p_purity_real_show]}
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Chenodeoxycholic acid 生物活性

描述 Chenodeoxycholic acid, also named as chenic acid, is one of the major biliary bile acids in human[1]. In vitro studies, chenodeoxycholic acid could effectively inhibit the proteolytic activity of pepsin against n-APDT[2]. In vivo studies, it was found that neonates would have a significantly greater pool of chenodeoxycholic acid (CDCA) when 0.25% CDCA was fed to pregnant rats, while CDCA would have no hepatotoxic effects on maternal and neonatal[3]. Besides this, chronic administration of chenodeoxycholic acid could contribute to the increasing of cholesterol saturation in bile of dogs when given 200 mg/day for 15 days[4].

Chenodeoxycholic acid 参考文献

[1]Iser JH, Sali A. Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use. Drugs. 1981;21(2):90-119.

[2]Eto T, Tompkins RK. Inhibition of pepsin activity by ursodeoxycholic acids and chenodeoxycholic acids. Am J Surg. 1985;150(5):564-7.

[3]Sprinkle DJ, Hassan AS, et al. Effect of chenodeoxycholic acid feeding during gestation in the rat on bile acid metabolism and liver morphology. Proc Soc Exp Biol Med. 1984;175(3):386-97.

[4]Poupon RE, Poupon RY, et al. Chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile in the dog. Eur J Clin Invest. 1979;9(1):103-5.

Chenodeoxycholic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.47mL

5.09mL

2.55mL

Chenodeoxycholic acid 技术信息

CAS号474-25-9
分子式C24H40O4
分子量 392.572
别名 CDCA
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature
溶解度

DMSO: 50 mg/mL(127.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

0.1 M NaOH: 50 mg/mL(127.37 mM)，配合低频超声，并调节pH至8
动物实验配方

Tags: Chenodeoxycholic acid | CDCA | Drug Standard | AmBeed-信号通路专用抑制剂 | Chenodeoxycholic acid 纯度/质量文件 | Chenodeoxycholic acid 生物活性 | Chenodeoxycholic acid 参考文献 | Chenodeoxycholic acid 实验方案 | Chenodeoxycholic acid 技术信息

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