Chenodeoxycholic acid

产品说明书

Print
Chemical Structure| 474-25-9 同义名 : CDCA
CAS号 : 474-25-9
货号 : A342210
分子式 : C24H40O4
纯度 : 98+%
分子量 : 392.572
MDL号 : MFCD00064142
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(127.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

0.1 M NaOH: 50 mg/mL(127.37 mM)，配合低频超声，并调节pH至8
动物实验配方：
生物活性
描述 Chenodeoxycholic acid, also named as chenic acid, is one of the major biliary bile acids in human[1]. In vitro studies, chenodeoxycholic acid could effectively inhibit the proteolytic activity of pepsin against n-APDT[2]. In vivo studies, it was found that neonates would have a significantly greater pool of chenodeoxycholic acid (CDCA) when 0.25% CDCA was fed to pregnant rats, while CDCA would have no hepatotoxic effects on maternal and neonatal[3]. Besides this, chronic administration of chenodeoxycholic acid could contribute to the increasing of cholesterol saturation in bile of dogs when given 200 mg/day for 15 days[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.47mL

5.09mL

2.55mL
参考文献

[1]Iser JH, Sali A. Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use. Drugs. 1981;21(2):90-119.

[2]Eto T, Tompkins RK. Inhibition of pepsin activity by ursodeoxycholic acids and chenodeoxycholic acids. Am J Surg. 1985;150(5):564-7.

[3]Sprinkle DJ, Hassan AS, et al. Effect of chenodeoxycholic acid feeding during gestation in the rat on bile acid metabolism and liver morphology. Proc Soc Exp Biol Med. 1984;175(3):386-97.

[4]Poupon RE, Poupon RY, et al. Chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile in the dog. Eur J Clin Invest. 1979;9(1):103-5.