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头孢呋辛钠 /Cefuroxime Sodium {[allProObj[0].p_purity_real_show]}

货号:A572389 同义名: Cefuroxime (sodium salt)

Cefuroxime Sodium是一种第二代头孢菌素抗生素,具有广谱抗菌活性,能抵抗 β-内酰胺酶降解,广泛用于革兰阳性和阴性细菌感染的研究与治疗,半衰期约为 80 分钟。

Cefuroxime Sodium 化学结构 CAS号:56238-63-2
Cefuroxime Sodium 化学结构
CAS号:56238-63-2
Cefuroxime Sodium 3D分子结构
CAS号:56238-63-2
Cefuroxime Sodium 化学结构 CAS号:56238-63-2
Cefuroxime Sodium 3D分子结构 CAS号:56238-63-2
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Cefuroxime Sodium 纯度/质量文件 产品仅供科研

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Cefuroxime Sodium 生物活性

描述 Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant; Streptococcus pyogenes; S. pneumonia; S. viridans; S. faecalis and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively. It is highly active against Neisseria gonorrhoeae, Neisseria meningitidis, and also Haemophilus influenzae, including ampicillin-resistant strains. Cefuroxime is rapidly bactericidal and induces the formation and subsequent lysis of filamentous forms over a small concentration range[2]. Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime sodium is 3 mg/kg as a result of the protection test[3]. After both i.v. and intramuscular injections of cefuroxime sodium, the concentrations of cefuroxime in urine were much higher than that in serum. The systemic bioavailability of cefuroxime sodium in goats after intramuscular injections of 20 and 40 mg/kg body weight was 88.4 percent and 103.5 percent, respectively. In vitro protein binding of cefuroxime sodium in goat's serum was low, ranging from 13.3 percent to 21.6 percent with an average of 17.0 percent[4].

Cefuroxime Sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03216642 - Recruiting April 17, 2018 China, Guangdong ... 展开 >> Clinical Research Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Wang Zhichong, M.D.    02087333391    wzc001@hotmail.com    Contact: Liu Chengxiu    02087333391    13760787745@163.com 收起 <<
NCT00355602 Colitis, Ulcerative Not Applicable Completed - United Kingdom ... 展开 >> Ninewells Hospital and Medical School Dundee, Angus, United Kingdom, DD1 9SY 收起 <<
NCT02171338 Pneumonia Acu... 展开 >>te Exacerbation of Chronic Obstructive Airways Disease 收起 << Phase 4 Unknown September 2014 Denmark ... 展开 >> Holbæk Hospital Holbæk, Denmark, 4300 收起 <<

Cefuroxime Sodium 参考文献

[1]Capel-Edwards K, Atkinson RM, et al. Toxicological studies on cefuroxime sodium. Toxicology. 1979 May;13(1):1-5.

[2]O'Callaghan CH, Sykes RB, Griffiths A, Thornton JE. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976;9(3):511-519

[3]Ryan DM, O'Callaghan C, Muggleton PW. Cefuroxime, a new cephalosporin antibiotic: activity in vivo. Antimicrob Agents Chemother. 1976;9(3):520-525

[4]ABO EL-SOOUD K, El-Banna HA, Hanafy MS, Goudah A. Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats. Res Vet Sci. 2000;69(3):219-224

Cefuroxime Sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL

Cefuroxime Sodium 技术信息

CAS号56238-63-2
分子式C16H15N4NaO8S
分子量 446.367
别名 Cefuroxime (sodium salt)
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C

溶解方案

DMSO: 105 mg/mL(235.23 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(112.02 mM),配合低频超声助溶

动物实验配方
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