Cefuroxime Sodium

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Chemical Structure| 56238-63-2 同义名 : Cefuroxime (sodium salt)
CAS号 : 56238-63-2
货号 : A572389
分子式 : C16H15N4NaO8S
纯度 : 98%
分子量 : 446.367
MDL号 : MFCD09878727
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(235.23 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(112.02 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant; Streptococcus pyogenes; S. pneumonia; S. viridans; S. faecalis and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively. It is highly active against Neisseria gonorrhoeae, Neisseria meningitidis, and also Haemophilus influenzae, including ampicillin-resistant strains. Cefuroxime is rapidly bactericidal and induces the formation and subsequent lysis of filamentous forms over a small concentration range[2]. Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime sodium is 3 mg/kg as a result of the protection test[3]. After both i.v. and intramuscular injections of cefuroxime sodium, the concentrations of cefuroxime in urine were much higher than that in serum. The systemic bioavailability of cefuroxime sodium in goats after intramuscular injections of 20 and 40 mg/kg body weight was 88.4 percent and 103.5 percent, respectively. In vitro protein binding of cefuroxime sodium in goat's serum was low, ranging from 13.3 percent to 21.6 percent with an average of 17.0 percent[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03216642 - Recruiting April 17, 2018 China, Guangdong ... 展开 >> Clinical Research Center Recruiting Guangzhou, Guangdong, China, 510000 Contact: Wang Zhichong, M.D.    02087333391    wzc001@hotmail.com    Contact: Liu Chengxiu    02087333391    13760787745@163.com 收起 <<
NCT00355602 Colitis, Ulcerative Not Applicable Completed - United Kingdom ... 展开 >> Ninewells Hospital and Medical School Dundee, Angus, United Kingdom, DD1 9SY 收起 <<
NCT02171338 Pneumonia Acu... 展开 >>te Exacerbation of Chronic Obstructive Airways Disease 收起 << Phase 4 Unknown September 2014 Denmark ... 展开 >> Holbæk Hospital Holbæk, Denmark, 4300 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL
参考文献

[1]Capel-Edwards K, Atkinson RM, et al. Toxicological studies on cefuroxime sodium. Toxicology. 1979 May;13(1):1-5.

[2]O'Callaghan CH, Sykes RB, Griffiths A, Thornton JE. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976;9(3):511-519

[3]Ryan DM, O'Callaghan C, Muggleton PW. Cefuroxime, a new cephalosporin antibiotic: activity in vivo. Antimicrob Agents Chemother. 1976;9(3):520-525

[4]ABO EL-SOOUD K, El-Banna HA, Hanafy MS, Goudah A. Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats. Res Vet Sci. 2000;69(3):219-224