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头孢曲松钠 /Ceftriaxone sodium hydrate {[allProObj[0].p_purity_real_show]}

货号:A487798 同义名: 头孢曲松钠水合物 / Ro 13-9904 sodium hydrate;Ceftriaxone (sodium salt hydrate)

Ceftriaxone Sodium Hydrate is the third-generation cephalosporin useful for the treatment of a number of bacterial infections.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ceftriaxone sodium hydrate 化学结构 CAS号:104376-79-6
Ceftriaxone sodium hydrate 化学结构
CAS号:104376-79-6
Ceftriaxone sodium hydrate 3D分子结构
CAS号:104376-79-6
Ceftriaxone sodium hydrate 化学结构 CAS号:104376-79-6
Ceftriaxone sodium hydrate 3D分子结构 CAS号:104376-79-6
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Ceftriaxone sodium hydrate 纯度/质量文件 产品仅供科研

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Ceftriaxone sodium hydrate 生物活性

描述 Ceftriaxone sodium (trihydrate), one of the beta-lactam antibiotics, is a third-generation semi-synthetic antibiotic belonging to the class of cephalosporins. It has bactericidal action; its main activity is related to the Gram-negative bacteria, being also able to act against Gram-negative bacilli resistant to the first- and second-generation cephalosporins[2]. Ceftriaxone is a stimulator of EAAT2 (Excitatory amino acid transporter2) expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity[3]. Long term ceftriaxone sodium administration resulted in gut microbiota dysbiosis, intestine histological lesions, growth inhibition, spleen index reducing. Not only the immune defense, long term ceftriaxone administration also affected immune regulation[4].

Ceftriaxone sodium hydrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00002052 HIV Infections ... 展开 >> Salmonella Infections 收起 << Not Applicable Completed - United States, California ... 展开 >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 收起 <<

Ceftriaxone sodium hydrate 参考文献

[1]Brogden RN, Ward A. Ceftriaxone. A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration. Drugs. 1988 Jun;35(6):604-45.

[2]da Trindade MT, Salgado HRN. A Critical Review of Analytical Methods for Determination of Ceftriaxone Sodium. Crit Rev Anal Chem. 2018 Mar 4;48(2):95-101.

[3]Lee SG, Su ZZ, Emdad L, Gupta P, Sarkar D, Borjabad A, Volsky DJ, Fisher PB. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem. 2008 May 9;283(19):13116-23.

[4]Guo Y, Yang X, Qi Y, Wen S, Liu Y, Tang S, Huang R, Tang L. Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system. Sci Rep. 2017 Feb 21;7:43035.

Ceftriaxone sodium hydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.38mL

0.28mL

0.14mL

6.90mL

1.38mL

0.69mL

13.80mL

2.76mL

1.38mL

Ceftriaxone sodium hydrate 技术信息

CAS号104376-79-6
分子式C18H30N8Na2O14S3
分子量 724.65
别名 头孢曲松钠水合物 ;Ro 13-9904 sodium hydrate;Ceftriaxone (sodium salt hydrate);Rosihlitazone;Ro 13-9904;Ceftriaxone disodium hemiheptahydrate;heptahydrate;Ceftriaxone disodium salt hemi
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度
动物实验配方
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