产品说明书

	同义名 :	头孢曲松钠水合物 ;Ro 13-9904 sodium hydrate;Ceftriaxone (sodium salt hydrate);Rosihlitazone;Ro 13-9904;Ceftriaxone disodium hemiheptahydrate;heptahydrate;Ceftriaxone disodium salt hemi
	CAS号 :	104376-79-6
	货号 :	A487798
	分子式 :	C18H30N8Na2O14S3
	纯度 :	99+%
	分子量 :	724.65
	MDL号 :	MFCD01750405
	存储条件：	粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Ceftriaxone sodium (trihydrate), one of the beta-lactam antibiotics, is a third-generation semi-synthetic antibiotic belonging to the class of cephalosporins. It has bactericidal action; its main activity is related to the Gram-negative bacteria, being also able to act against Gram-negative bacilli resistant to the first- and second-generation cephalosporins[2]. Ceftriaxone is a stimulator of EAAT2 (Excitatory amino acid transporter2) expression with neuroprotective effects in both in vitro and in vivo models based in part on its ability to inhibit neuronal cell death by glutamate excitotoxicity[3]. Long term ceftriaxone sodium administration resulted in gut microbiota dysbiosis, intestine histological lesions, growth inhibition, spleen index reducing. Not only the immune defense, long term ceftriaxone administration also affected immune regulation[4].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00002052	HIV Infections ... 展开 >> Salmonella Infections 收起 <<	Not Applicable	Completed	-	United States, California ... 展开 >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.38mL 0.28mL 0.14mL	6.90mL 1.38mL 0.69mL	13.80mL 2.76mL 1.38mL

参考文献

[1]Brogden RN, Ward A. Ceftriaxone. A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration. Drugs. 1988 Jun;35(6):604-45. [2]da Trindade MT, Salgado HRN. A Critical Review of Analytical Methods for Determination of Ceftriaxone Sodium. Crit Rev Anal Chem. 2018 Mar 4;48(2):95-101. [3]Lee SG, Su ZZ, Emdad L, Gupta P, Sarkar D, Borjabad A, Volsky DJ, Fisher PB. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J Biol Chem. 2008 May 9;283(19):13116-23. [4]Guo Y, Yang X, Qi Y, Wen S, Liu Y, Tang S, Huang R, Tang L. Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system. Sci Rep. 2017 Feb 21;7:43035.