Cefpirome Sulfate (CPR) is an injectable extended-spectrum or 'fourth generation' cephalosporin. Its antibacterial activity encompasses many of the pathogens involved in hospital-acquired infections such as enterobacteriaceae, methicillin-susceptible staphylococcus aureus, coagulase-negative staphylococci and viridans group streptococci. The tolerability of cefpirome appears similar to that of ceftazidime and other third generation cephalosporins, diarrhoea being the most frequently observed event[3]. Cefpirome sulfate caused strong quenching of the fluorescence of lysozyme by a static quenching mechanism[4]. When cefpirome sulfate was injected intracutaneously at a high concentration of 20%, its irritating effects were only equal to or slightly stronger than those of distilled water for injection and Na2SO4 solution[5].
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